Found 42 hits for monomerid = 50262079 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Bone morphogenetic protein
(Danio rerio (Zebrafish)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a |
Vanderbilt University
| Assay Description The effects on zebrafish embryos with respect to the dorsoventral (DV) axis. For dorsalization, the EC100 (effective concentration 100%) represents t... |
ACS Chem Biol 5: 245-53 (2010)
Article DOI: 10.1021/cb9002865 BindingDB Entry DOI: 10.7270/Q2JW8C78 |
More data for this Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB
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| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by ChEMBL
| Assay Description Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assay |
J Med Chem 63: 4978-4996 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00395 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Bone morphogenetic protein
(Danio rerio (Zebrafish)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | UniProtKB/TrEMBL
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| n/a | n/a | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a |
Vanderbilt University
| Assay Description For nonspecific toxicity, the EC100 represents the concentration when 100% of the treated embryos exhibit either early lethality within hours of comp... |
ACS Chem Biol 5: 245-53 (2010)
Article DOI: 10.1021/cb9002865 BindingDB Entry DOI: 10.7270/Q2JW8C78 |
More data for this Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB
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| n/a | n/a | 40.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
| Assay Description Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human... |
ACS Chem Biol 5: 245-53 (2010)
Article DOI: 10.1021/cb9002865 BindingDB Entry DOI: 10.7270/Q2JW8C78 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
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| n/a | n/a | 565 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
| Assay Description Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human... |
ACS Chem Biol 5: 245-53 (2010)
Article DOI: 10.1021/cb9002865 BindingDB Entry DOI: 10.7270/Q2JW8C78 |
More data for this Ligand-Target Pair | |
AMP-activated protein kinase (AMPK)
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB
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antibodypedia antibodypedia GoogleScholar AffyNet
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| n/a | n/a | 1.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
| Assay Description Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human... |
ACS Chem Biol 5: 245-53 (2010)
Article DOI: 10.1021/cb9002865 BindingDB Entry DOI: 10.7270/Q2JW8C78 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 215 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
| Assay Description Shown are the IC50s (concentrations causing 50% inhibition) of DM and the analogues for the in vitro kinase assays using the following purified human... |
ACS Chem Biol 5: 245-53 (2010)
Article DOI: 10.1021/cb9002865 BindingDB Entry DOI: 10.7270/Q2JW8C78 |
More data for this Ligand-Target Pair | |
ALK1
(Mus musculus) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
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| n/a | n/a | 1.48 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology
| |
ACS Chem Biol 8: 1291-302 (2013)
Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
ALK2
(Mus musculus) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
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| n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology
| |
ACS Chem Biol 8: 1291-302 (2013)
Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
ALK3
(Mus musculus) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
Reactome pathway KEGG
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| n/a | n/a | 14.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology
| |
ACS Chem Biol 8: 1291-302 (2013)
Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
ALK4
(Mus musculus) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB
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| n/a | n/a | 108 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts Institute of Technology
| |
ACS Chem Biol 8: 1291-302 (2013)
Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW |
More data for this Ligand-Target Pair | |
ALK5
(Mus musculus) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB
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Massachusetts Institute of Technology
| |
ACS Chem Biol 8: 1291-302 (2013)
Article DOI: 10.1021/cb300655w BindingDB Entry DOI: 10.7270/Q2ZW1JKW |
More data for this Ligand-Target Pair | |
Bone morphogenetic protein 4
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description Inhibition of BMP4 (unknown origin)-induced phosphorylation of SMAD 1/5/8 by cytoblot cellular ELISA |
Bioorg Med Chem Lett 18: 4388-92 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.052 BindingDB Entry DOI: 10.7270/Q2BR8S0V |
More data for this Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1B (BMPR1B) aa 168-495
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | UniProtKB/SwissProt
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description Inhibition of ALK6 (unknown origin) |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113 BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB
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| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description Inhibition of ALK2 (unknown origin) |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113 BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Serine/threonine-protein kinase receptor R3
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
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| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description Inhibition of ALK1 (unknown origin) |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113 BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Bone morphogenetic protein receptor type-2
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 3.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description Inhibition of BMPR2 (unknown origin) |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113 BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this Ligand-Target Pair | |
Activin receptor type-1B
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 1.83E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description Inhibition of ALK4 (unknown origin) |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113 BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this Ligand-Target Pair | |
5'-AMP-activated protein kinase subunit beta-1
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB
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| Article PubMed
| n/a | n/a | 1.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description Inhibition of AMPK (unknown origin) |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113 BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
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CHEMBL PC cid PC sid PDB UniChem
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| Article PubMed
| n/a | n/a | 565 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description Inhibition of ALK5 (unknown origin) |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113 BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this Ligand-Target Pair | |
TGF-beta receptor type II
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description Inhibition of TGFBR2 (unknown origin) |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113 BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase receptor R3
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
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| PDB PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of human ALK1 using casein as substrate in presence of 10 uM ATP by radiometric kinase assay |
J Med Chem 60: 1495-1508 (2017)
BindingDB Entry DOI: 10.7270/Q2TQ63S4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB
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| PDB PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of human ALK2 using casein as substrate in presence of 10 uM ATP by radiometric kinase assay |
J Med Chem 60: 1495-1508 (2017)
BindingDB Entry DOI: 10.7270/Q2TQ63S4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Activin receptor-like kinase 3 (ALK-3)
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB
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| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of human ALK3 using casein as substrate in presence of 10 uM ATP by radiometric kinase assay |
J Med Chem 60: 1495-1508 (2017)
BindingDB Entry DOI: 10.7270/Q2TQ63S4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Activin receptor type-1B
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
Reactome pathway KEGG
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| PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of human ALK4 using casein as substrate in presence of 10 uM ATP by radiometric kinase assay |
J Med Chem 60: 1495-1508 (2017)
BindingDB Entry DOI: 10.7270/Q2TQ63S4 |
More data for this Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1B (BMPR1B) aa 168-495
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | UniProtKB/SwissProt
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| n/a | n/a | 0.940 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of human ALK6 using casein as substrate in presence of 10 uM ATP by radiometric kinase assay |
J Med Chem 60: 1495-1508 (2017)
BindingDB Entry DOI: 10.7270/Q2TQ63S4 |
More data for this Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of human ALK5 using casein as substrate in presence of 10 uM ATP by radiometric kinase assay |
J Med Chem 60: 1495-1508 (2017)
BindingDB Entry DOI: 10.7270/Q2TQ63S4 |
More data for this Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB
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| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description Inhibition of ALK2 (unknown origin) using Ulight topo IIa (Thr 1342) peptide as substrate preincubated for 10 mins followed by substrate addition and... |
Bioorg Med Chem Lett 28: 3356-3362 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.006 BindingDB Entry DOI: 10.7270/Q2NZ8BBT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
ALK2
(Mus musculus) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
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| n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description Inhibition of BMP6-induced ALK2 transcriptional activity in mouse C2C12 cells expressing BRE-Luc after 30 mins by luciferase reporter gene assay |
Bioorg Med Chem Lett 28: 3356-3362 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.006 BindingDB Entry DOI: 10.7270/Q2NZ8BBT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Activin receptor-like kinase 3 (ALK-3)
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB
UniProtKB/SwissProt
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| PDB Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description Inhibition of ALK3 (unknown origin) using Ulight topo IIa (Thr 1342) peptide as substrate preincubated for 10 mins followed by substrate addition and... |
Bioorg Med Chem Lett 28: 3356-3362 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.006 BindingDB Entry DOI: 10.7270/Q2NZ8BBT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
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| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TU Dortmund University
Curated by ChEMBL
| Assay Description Inhibition of human ALK5 in presence of (33P)gamma ATP |
J Med Chem 58: 9451-79 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00446 BindingDB Entry DOI: 10.7270/Q2125WNS |
More data for this Ligand-Target Pair | |
Activin receptor-like kinase 3 (ALK-3)
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB
UniProtKB/SwissProt
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| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description Inhibition of human ALK3 using casein as substrate by [gamma-33P]-ATP assay |
Eur J Med Chem 161: 456-467 (2019)
Article DOI: 10.1016/j.ejmech.2018.10.052 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
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| Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description Inhibition of human ALK5 using casein as substrate by [gamma-33P]-ATP assay |
Eur J Med Chem 161: 456-467 (2019)
Article DOI: 10.1016/j.ejmech.2018.10.052 |
More data for this Ligand-Target Pair | |
Bone morphogenetic protein receptor type-1B (BMPR1B) aa 168-495
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description Inhibition of human ALK6 using casein as substrate by [gamma-33P]-ATP assay |
Eur J Med Chem 161: 456-467 (2019)
Article DOI: 10.1016/j.ejmech.2018.10.052 |
More data for this Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB
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| PDB Article PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description Inhibition of human ALK2 using casein as substrate by [gamma-33P]-ATP assay |
Eur J Med Chem 161: 456-467 (2019)
Article DOI: 10.1016/j.ejmech.2018.10.052 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Serine/threonine-protein kinase receptor R3
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description Inhibition of human ALK1 using casein as substrate by [gamma-33P]-ATP assay |
Eur J Med Chem 161: 456-467 (2019)
Article DOI: 10.1016/j.ejmech.2018.10.052 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Activin receptor type-1B
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description Inhibition of human ALK4 using casein as substrate by [gamma-33P]-ATP assay |
Eur J Med Chem 161: 456-467 (2019)
Article DOI: 10.1016/j.ejmech.2018.10.052 |
More data for this Ligand-Target Pair | |
TGF-beta receptor type II
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description Inhibition of human TGFBR2 using MBP as substrate by [gamma-33P]-ATP assay |
Eur J Med Chem 161: 456-467 (2019)
Article DOI: 10.1016/j.ejmech.2018.10.052 |
More data for this Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
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| Article PubMed
| n/a | n/a | 468 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by ChEMBL
| Assay Description Inhibition of human ALK5 using dephosphorylated casein as substrate measured after 45 mins in presence of [gamma33P]ATP by scintillation counting met... |
J Med Chem 63: 4978-4996 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00395 |
More data for this Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | 468 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by ChEMBL
| Assay Description Inhibition of human ALK5 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assay |
J Med Chem 63: 4978-4996 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00395 |
More data for this Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by ChEMBL
| Assay Description Inhibition of human ALK2 using dephosphorylated casein as substrate measured after 45 mins in presence of [gamma33P]ATP by scintillation counting met... |
J Med Chem 63: 4978-4996 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00395 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Bone morphogenetic protein
(Danio rerio (Zebrafish)) | BDBM50262079
(4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | UniProtKB/TrEMBL
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CHEMBL PC cid PC sid PDB UniChem
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| n/a | n/a | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a |
Vanderbilt University
| Assay Description For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited. |
ACS Chem Biol 5: 245-53 (2010)
Article DOI: 10.1021/cb9002865 BindingDB Entry DOI: 10.7270/Q2JW8C78 |
More data for this Ligand-Target Pair | |