BDBM50262085 CHEMBL468397::methyl 5-((3-(1H-benzo[d]imidazol-2-yl)propyl)(methyl)amino)-2-(4-bromophenyl)-2-isopropylpentanoate

SMILES: COC(=O)C(CCCN(C)CCCc1nc2ccccc2[nH]1)(C(C)C)c1ccc(Br)cc1

InChI Key: InChIKey=DUAKQKCVTZFHSD-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50262085   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-gated T-type calcium channel (Homo sapiens (Human))	BDBM50262085 (CHEMBL468397 | methyl 5-((3-(1H-benzo[d]imidazol-2...) Show SMILES COC(=O)C(CCCN(C)CCCc1nc2ccccc2[nH]1)(C(C)C)c1ccc(Br)cc1 Show InChI InChI=1S/C26H34BrN3O2/c1-19(2)26(25(31)32-4,20-12-14-21(27)15-13-20)16-8-18-30(3)17-7-11-24-28-22-9-5-6-10-23(22)29-24/h5-6,9-10,12-15,19H,7-8,11,16-18H2,1-4H3,(H,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.17	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Science and Technology Curated by ChEMBL					Assay Description Antagonist activity at T type calcium channel alpha1G (unknown origin) expressed in HEK293 cells assessed as inhibition of peak currents by whole-cel...				Bioorg Med Chem Lett 18: 4424-7 (2008) Article DOI: 10.1016/j.bmcl.2008.06.037 BindingDB Entry DOI: 10.7270/Q2TT4QRD
					More data for this Ligand-Target Pair
Voltage-gated T-type calcium channel (Homo sapiens (Human))	BDBM50262085 (CHEMBL468397 | methyl 5-((3-(1H-benzo[d]imidazol-2...) Show SMILES COC(=O)C(CCCN(C)CCCc1nc2ccccc2[nH]1)(C(C)C)c1ccc(Br)cc1 Show InChI InChI=1S/C26H34BrN3O2/c1-19(2)26(25(31)32-4,20-12-14-21(27)15-13-20)16-8-18-30(3)17-7-11-24-28-22-9-5-6-10-23(22)29-24/h5-6,9-10,12-15,19H,7-8,11,16-18H2,1-4H3,(H,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.17	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Science and Technology Curated by ChEMBL					Assay Description Antagonist activity at T type calcium channel alpha1G (unknown origin) expressed in HEK293 cells assessed as inhibition of peak currents at 1 uM by w...				Bioorg Med Chem Lett 18: 4424-7 (2008) Article DOI: 10.1016/j.bmcl.2008.06.037 BindingDB Entry DOI: 10.7270/Q2TT4QRD
					More data for this Ligand-Target Pair
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae)	BDBM50262085 (CHEMBL468397 | methyl 5-((3-(1H-benzo[d]imidazol-2...) Show SMILES COC(=O)C(CCCN(C)CCCc1nc2ccccc2[nH]1)(C(C)C)c1ccc(Br)cc1 Show InChI InChI=1S/C26H34BrN3O2/c1-19(2)26(25(31)32-4,20-12-14-21(27)15-13-20)16-8-18-30(3)17-7-11-24-28-22-9-5-6-10-23(22)29-24/h5-6,9-10,12-15,19H,7-8,11,16-18H2,1-4H3,(H,28,29)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	178	n/a	n/a	n/a	n/a	n/a	n/a
The Catholic University of Korea Curated by ChEMBL					Assay Description Inhibition of human ERG by whole-cell patch clamp method				Bioorg Med Chem Lett 24: 880-3 (2014) Article DOI: 10.1016/j.bmcl.2013.12.078 BindingDB Entry DOI: 10.7270/Q2C53PSG
					More data for this Ligand-Target Pair
Voltage-gated T-type calcium channel (Homo sapiens (Human))	BDBM50262085 (CHEMBL468397 | methyl 5-((3-(1H-benzo[d]imidazol-2...) Show SMILES COC(=O)C(CCCN(C)CCCc1nc2ccccc2[nH]1)(C(C)C)c1ccc(Br)cc1 Show InChI InChI=1S/C26H34BrN3O2/c1-19(2)26(25(31)32-4,20-12-14-21(27)15-13-20)16-8-18-30(3)17-7-11-24-28-22-9-5-6-10-23(22)29-24/h5-6,9-10,12-15,19H,7-8,11,16-18H2,1-4H3,(H,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
The Catholic University of Korea Curated by ChEMBL					Assay Description Inhibition of T-type calcium channel subunit alpha-1G (unknown origin) expressed in HEK293 cells assessed as inactivation of channel current at holdi...				Bioorg Med Chem Lett 24: 880-3 (2014) Article DOI: 10.1016/j.bmcl.2013.12.078 BindingDB Entry DOI: 10.7270/Q2C53PSG
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50262085 (CHEMBL468397 | methyl 5-((3-(1H-benzo[d]imidazol-2...) Show SMILES COC(=O)C(CCCN(C)CCCc1nc2ccccc2[nH]1)(C(C)C)c1ccc(Br)cc1 Show InChI InChI=1S/C26H34BrN3O2/c1-19(2)26(25(31)32-4,20-12-14-21(27)15-13-20)16-8-18-30(3)17-7-11-24-28-22-9-5-6-10-23(22)29-24/h5-6,9-10,12-15,19H,7-8,11,16-18H2,1-4H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	178	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Science and Technology Curated by ChEMBL					Assay Description Inhibition of human ERG channel				Bioorg Med Chem Lett 18: 4424-7 (2008) Article DOI: 10.1016/j.bmcl.2008.06.037 BindingDB Entry DOI: 10.7270/Q2TT4QRD
					More data for this Ligand-Target Pair