BDBM50262627 CHEMBL476313::Propane-1-sulfonic acid biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-amide
SMILES: CCCS(=O)(=O)N(Cc1ccccc1-c1ccccc1)[C@H]1CCNC1
InChI Key: InChIKey=BYZZRTNQROTLCL-IBGZPJMESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50262627 (CHEMBL476313 | Propane-1-sulfonic acid biphenyl-2-...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPA | Bioorg Med Chem Lett 18: 4355-9 (2008) Article DOI: 10.1016/j.bmcl.2008.06.071 BindingDB Entry DOI: 10.7270/Q2GH9HRM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50262627 (CHEMBL476313 | Propane-1-sulfonic acid biphenyl-2-...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cells by SPA | Bioorg Med Chem Lett 18: 4355-9 (2008) Article DOI: 10.1016/j.bmcl.2008.06.071 BindingDB Entry DOI: 10.7270/Q2GH9HRM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50262627 (CHEMBL476313 | Propane-1-sulfonic acid biphenyl-2-...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.68E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of [3H]citalopram uptake at human 5HTT expressed in HEK293 cells by SPA | Bioorg Med Chem Lett 18: 4355-9 (2008) Article DOI: 10.1016/j.bmcl.2008.06.071 BindingDB Entry DOI: 10.7270/Q2GH9HRM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50262627 (CHEMBL476313 | Propane-1-sulfonic acid biphenyl-2-...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 185 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of CYP2D6 (unknown origin) | Bioorg Med Chem Lett 18: 4355-9 (2008) Article DOI: 10.1016/j.bmcl.2008.06.071 BindingDB Entry DOI: 10.7270/Q2GH9HRM | |||||||||||
More data for this Ligand-Target Pair |