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BDBM50262673 6-Methyl-biphenyl-3,4'-dicarboxylic acid 4'-cyclopropylmethyl-amide 3-thiazol-2-ylamide::CHEMBL478614

SMILES: Cc1ccc(cc1-c1ccc(cc1)C(=O)NCC1CC1)C(=O)Nc1nccs1

InChI Key: InChIKey=HIOYZPRTZOZNTQ-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50262673   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50262673
PNG
(6-Methyl-biphenyl-3,4'-dicarboxylic acid 4'-cyclop...)
Show SMILES Cc1ccc(cc1-c1ccc(cc1)C(=O)NCC1CC1)C(=O)Nc1nccs1
Show InChI InChI=1S/C22H21N3O2S/c1-14-2-5-18(21(27)25-22-23-10-11-28-22)12-19(14)16-6-8-17(9-7-16)20(26)24-13-15-3-4-15/h2,5-12,15H,3-4,13H2,1H3,(H,24,26)(H,23,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
14n/an/an/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Displacement of rhodamine-green labelled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]pheny...


Bioorg Med Chem Lett 18: 4428-32 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.048
BindingDB Entry DOI: 10.7270/Q2CR5T5P
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50262673
PNG
(6-Methyl-biphenyl-3,4'-dicarboxylic acid 4'-cyclop...)
Show SMILES Cc1ccc(cc1-c1ccc(cc1)C(=O)NCC1CC1)C(=O)Nc1nccs1
Show InChI InChI=1S/C22H21N3O2S/c1-14-2-5-18(21(27)25-22-23-10-11-28-22)12-19(14)16-6-8-17(9-7-16)20(26)24-13-15-3-4-15/h2,5-12,15H,3-4,13H2,1H3,(H,24,26)(H,23,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 86n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Displacement of rhodamine-green labelled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]pheny...


Bioorg Med Chem Lett 18: 4428-32 (2008)


Article DOI: 10.1016/j.bmcl.2008.06.048
BindingDB Entry DOI: 10.7270/Q2CR5T5P
More data for this
Ligand-Target Pair