BDBM50262677 Biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-carbamic acid methyl ester::CHEMBL517978

SMILES: COC(=O)N(Cc1ccccc1-c1ccccc1)[C@H]1CCNC1

InChI Key: InChIKey=JTVKAFWSBOMWKU-KRWDZBQOSA-N

Data: 3 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50262677   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50262677 (Biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-carbamic a...) Show SMILES COC(=O)N(Cc1ccccc1-c1ccccc1)[C@H]1CCNC1 |r| Show InChI InChI=1S/C19H22N2O2/c1-23-19(22)21(17-11-12-20-13-17)14-16-9-5-6-10-18(16)15-7-3-2-4-8-15/h2-10,17,20H,11-14H2,1H3/t17-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPA				Bioorg Med Chem Lett 18: 4355-9 (2008) Article DOI: 10.1016/j.bmcl.2008.06.071 BindingDB Entry DOI: 10.7270/Q2GH9HRM
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM50262677 (Biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-carbamic a...) Show SMILES COC(=O)N(Cc1ccccc1-c1ccccc1)[C@H]1CCNC1 |r| Show InChI InChI=1S/C19H22N2O2/c1-23-19(22)21(17-11-12-20-13-17)14-16-9-5-6-10-18(16)15-7-3-2-4-8-15/h2-10,17,20H,11-14H2,1H3/t17-/m0/s1	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.19E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cells by SPA				Bioorg Med Chem Lett 18: 4355-9 (2008) Article DOI: 10.1016/j.bmcl.2008.06.071 BindingDB Entry DOI: 10.7270/Q2GH9HRM
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50262677 (Biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-carbamic a...) Show SMILES COC(=O)N(Cc1ccccc1-c1ccccc1)[C@H]1CCNC1 |r| Show InChI InChI=1S/C19H22N2O2/c1-23-19(22)21(17-11-12-20-13-17)14-16-9-5-6-10-18(16)15-7-3-2-4-8-15/h2-10,17,20H,11-14H2,1H3/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.44E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of [3H]citalopram uptake at human 5HTT expressed in HEK293 cells by SPA				Bioorg Med Chem Lett 18: 4355-9 (2008) Article DOI: 10.1016/j.bmcl.2008.06.071 BindingDB Entry DOI: 10.7270/Q2GH9HRM
					More data for this Ligand-Target Pair
Cytochrome P450 2D6 (Homo sapiens (Human))	BDBM50262677 (Biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-carbamic a...) Show SMILES COC(=O)N(Cc1ccccc1-c1ccccc1)[C@H]1CCNC1 |r| Show InChI InChI=1S/C19H22N2O2/c1-23-19(22)21(17-11-12-20-13-17)14-16-9-5-6-10-18(16)15-7-3-2-4-8-15/h2-10,17,20H,11-14H2,1H3/t17-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.06E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of CYP2D6 (unknown origin)				Bioorg Med Chem Lett 18: 4355-9 (2008) Article DOI: 10.1016/j.bmcl.2008.06.071 BindingDB Entry DOI: 10.7270/Q2GH9HRM
					More data for this Ligand-Target Pair