BDBM50262935 CHEMBL515478::[3-(2-Ethoxyethyl)-2-methyl-5-(4-methylsulphonyl)phenyl-1-(4-trifluoromethyl)phenyl]-1Hpyrrole
SMILES: CCOCCc1cc(-c2ccc(cc2)S(C)(=O)=O)n(c1C)-c1ccc(cc1)C(F)(F)F
InChI Key: InChIKey=KTEYJBNCXYMANR-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cyclooxygenase-2 (COX-2) (Mus musculus (Mouse)) | BDBM50262935 (CHEMBL515478 | [3-(2-Ethoxyethyl)-2-methyl-5-(4-me...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita di Siena Curated by ChEMBL | Assay Description Inhibition of mouse COX2 in LPS-stimulated mouse J774 cells assessed as PGE2 production by radioimmunoassay | J Med Chem 51: 4476-81 (2008) Article DOI: 10.1021/jm800084s BindingDB Entry DOI: 10.7270/Q2KH0N55 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase (cyclooxygenase) (Mus musculus) | BDBM50262935 (CHEMBL515478 | [3-(2-Ethoxyethyl)-2-methyl-5-(4-me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita di Siena Curated by ChEMBL | Assay Description Inhibition of mouse COX1 in mouse J774 cells assessed as PGE2 production by radioimmunoassay | J Med Chem 51: 4476-81 (2008) Article DOI: 10.1021/jm800084s BindingDB Entry DOI: 10.7270/Q2KH0N55 | |||||||||||
More data for this Ligand-Target Pair |