BDBM50263384 6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazol-5-yl)nicotinamide::CHEMBL514691::SB-782443
SMILES: Cc1nc2cc(NC(=O)c3ccc(nc3C)-c3ccc(F)cc3)ccc2s1
InChI Key: InChIKey=QBATWTOFDFHEDZ-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Vanilloid receptor (Rattus norvegicus (rat)) | BDBM50263384 (6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | 5.3 | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5.3 acid-induced calcium influx by FLIPR assay | Bioorg Med Chem Lett 18: 5609-13 (2008) Article DOI: 10.1016/j.bmcl.2008.08.105 BindingDB Entry DOI: 10.7270/Q2PZ58PN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human)) | BDBM50263384 (6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium influx by whole cell patch clamp ass... | Bioorg Med Chem Lett 18: 5609-13 (2008) Article DOI: 10.1016/j.bmcl.2008.08.105 BindingDB Entry DOI: 10.7270/Q2PZ58PN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vanilloid receptor 1 (Cavia porcellus) | BDBM50263384 (6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 63 | n/a | n/a | n/a | n/a | 5.3 | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Antagonist activity at guinea pig TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5.3 acid-induced calcium influx by FLIPR assay | Bioorg Med Chem Lett 18: 5609-13 (2008) Article DOI: 10.1016/j.bmcl.2008.08.105 BindingDB Entry DOI: 10.7270/Q2PZ58PN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human)) | BDBM50263384 (6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | 5.3 | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5.3 acid-induced calcium influx by FLIPR assay | Bioorg Med Chem Lett 18: 5609-13 (2008) Article DOI: 10.1016/j.bmcl.2008.08.105 BindingDB Entry DOI: 10.7270/Q2PZ58PN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human)) | BDBM50263384 (6-(4-fluorophenyl)-2-methyl-N-(2-methylbenzothiazo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | 5.3 | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of pH 5.3 acid-induced calcium influx by whole cell patch clamp a... | Bioorg Med Chem Lett 18: 5609-13 (2008) Article DOI: 10.1016/j.bmcl.2008.08.105 BindingDB Entry DOI: 10.7270/Q2PZ58PN | |||||||||||
More data for this Ligand-Target Pair |