BDBM50263513 CHEMBL477172::N-(2-chloro-6-methylphenyl)-1-(6-(4-(morpholinomethyl)pyridin-2-ylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-amine

SMILES: Cc1cccc(Cl)c1Nc1nc2ccccc2n1-c1cc(Nc2cc(CN3CCOCC3)ccn2)ncn1

InChI Key: InChIKey=KNPRFHFPAKZBIG-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50263513   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50263513 (CHEMBL477172 | N-(2-chloro-6-methylphenyl)-1-(6-(4...) Show SMILES Cc1cccc(Cl)c1Nc1nc2ccccc2n1-c1cc(Nc2cc(CN3CCOCC3)ccn2)ncn1 Show InChI InChI=1S/C28H27ClN8O/c1-19-5-4-6-21(29)27(19)35-28-33-22-7-2-3-8-23(22)37(28)26-16-25(31-18-32-26)34-24-15-20(9-10-30-24)17-36-11-13-38-14-12-36/h2-10,15-16,18H,11-14,17H2,1H3,(H,33,35)(H,30,31,32,34)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as...				Bioorg Med Chem Lett 18: 5618-21 (2008) Article DOI: 10.1016/j.bmcl.2008.08.104 BindingDB Entry DOI: 10.7270/Q2DN44WQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50263513 (CHEMBL477172 | N-(2-chloro-6-methylphenyl)-1-(6-(4...) Show SMILES Cc1cccc(Cl)c1Nc1nc2ccccc2n1-c1cc(Nc2cc(CN3CCOCC3)ccn2)ncn1 Show InChI InChI=1S/C28H27ClN8O/c1-19-5-4-6-21(29)27(19)35-28-33-22-7-2-3-8-23(22)37(28)26-16-25(31-18-32-26)34-24-15-20(9-10-30-24)17-36-11-13-38-14-12-36/h2-10,15-16,18H,11-14,17H2,1H3,(H,33,35)(H,30,31,32,34)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of Lck by lance assay				Bioorg Med Chem Lett 18: 5618-21 (2008) Article DOI: 10.1016/j.bmcl.2008.08.104 BindingDB Entry DOI: 10.7270/Q2DN44WQ
					More data for this Ligand-Target Pair