BDBM50263516 CHEMBL450092::N4-(6-(2-(2-chloro-6-methylphenylamino)-1H-benzo[d]imidazol-1-yl)pyrimidin-4-yl)-2-methyl-N6-(2-morpholinoethyl)pyrimidine-4,6-diamine

SMILES: Cc1nc(NCCN2CCOCC2)cc(Nc2cc(ncn2)-n2c(Nc3c(C)cccc3Cl)nc3ccccc23)n1

InChI Key: InChIKey=SQUDMCTZEYADTE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50263516   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50263516 (CHEMBL450092 | N4-(6-(2-(2-chloro-6-methylphenylam...) Show SMILES Cc1nc(NCCN2CCOCC2)cc(Nc2cc(ncn2)-n2c(Nc3c(C)cccc3Cl)nc3ccccc23)n1 Show InChI InChI=1S/C29H31ClN10O/c1-19-6-5-7-21(30)28(19)38-29-36-22-8-3-4-9-23(22)40(29)27-17-25(32-18-33-27)37-26-16-24(34-20(2)35-26)31-10-11-39-12-14-41-15-13-39/h3-9,16-18H,10-15H2,1-2H3,(H,36,38)(H2,31,32,33,34,35,37)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as...				Bioorg Med Chem Lett 18: 5618-21 (2008) Article DOI: 10.1016/j.bmcl.2008.08.104 BindingDB Entry DOI: 10.7270/Q2DN44WQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50263516 (CHEMBL450092 | N4-(6-(2-(2-chloro-6-methylphenylam...) Show SMILES Cc1nc(NCCN2CCOCC2)cc(Nc2cc(ncn2)-n2c(Nc3c(C)cccc3Cl)nc3ccccc23)n1 Show InChI InChI=1S/C29H31ClN10O/c1-19-6-5-7-21(30)28(19)38-29-36-22-8-3-4-9-23(22)40(29)27-17-25(32-18-33-27)37-26-16-24(34-20(2)35-26)31-10-11-39-12-14-41-15-13-39/h3-9,16-18H,10-15H2,1-2H3,(H,36,38)(H2,31,32,33,34,35,37)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of TEL fused Lck (unknown origin)-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase as...				Bioorg Med Chem Lett 18: 5618-21 (2008) Article DOI: 10.1016/j.bmcl.2008.08.104 BindingDB Entry DOI: 10.7270/Q2DN44WQ
					More data for this Ligand-Target Pair