BDBM50263588 CHEMBL477616::ethyl 2-cyano-2-(3-ethyl-4-oxo-5-((4-(3-(2-(pyrrolidin-1-yl)ethyl)ureido)phenylamino)methylene)thiazolidin-2-ylidene)acetate

SMILES: CCOC(=O)C(\C#N)=c1/s\c(=C\Nc2ccc(NC(=O)NCCN3CCCC3)cc2)c(=O)n1CC

InChI Key: InChIKey=BIHLOOSBOOUCJL-VHDRYYFZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50263588   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50263588 (CHEMBL477616 | ethyl 2-cyano-2-(3-ethyl-4-oxo-5-((...) Show SMILES CCOC(=O)C(\C#N)=c1/s\c(=C\Nc2ccc(NC(=O)NCCN3CCCC3)cc2)c(=O)n1CC Show InChI InChI=1S/C24H30N6O4S/c1-3-30-21(31)20(35-22(30)19(15-25)23(32)34-4-2)16-27-17-7-9-18(10-8-17)28-24(33)26-11-14-29-12-5-6-13-29/h7-10,16,27H,3-6,11-14H2,1-2H3,(H2,26,28,33)/b20-16+,22-19-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Sichuan University Curated by ChEMBL					Assay Description Inhibition of PLK1 (unknown origin)				Bioorg Med Chem Lett 18: 4972-7 (2008) Article DOI: 10.1016/j.bmcl.2008.08.033 BindingDB Entry DOI: 10.7270/Q26973DV
					More data for this Ligand-Target Pair