new BindingDB logo
myBDB logout

BDBM50263669 (1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetrahydrocyclopropa[b]chromene-1a-carboxamide

SMILES: O=NC1[C@@H]2C[C@@]2(Oc2ccccc12)C(=O)Nc1ccccc1

InChI Key: InChIKey=UUGZPCXLWMAKDE-YRFPZCSCSA-N

Data: 1 IC50  7 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50263669   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50263669
PNG
((1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetr...)
Show SMILES O=NC1[C@@H]2C[C@@]2(Oc2ccccc12)C(=O)Nc1ccccc1 |r|
Show InChI InChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,15H,10H2,(H,18,20)/t13-,15?,17-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
n/an/a 3.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells.


Bioorg Med Chem Lett 6: 763-766 (1996)


Article DOI: 10.1016/0960-894X(96)00104-7
BindingDB Entry DOI: 10.7270/Q2WS8T7Q
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50263669
PNG
((1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetr...)
Show SMILES O=NC1[C@@H]2C[C@@]2(Oc2ccccc12)C(=O)Nc1ccccc1 |r|
Show InChI InChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,15H,10H2,(H,18,20)/t13-,15?,17-/m0/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a>5.00E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activity at human mGluR4 receptor expressed in CHO cells assessed as effect on calcium mobilization


J Med Chem 52: 4115-8 (2009)


Article DOI: 10.1021/jm9005065
BindingDB Entry DOI: 10.7270/Q2RJ4JHT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50263669
PNG
((1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetr...)
Show SMILES O=NC1[C@@H]2C[C@@]2(Oc2ccccc12)C(=O)Nc1ccccc1 |r|
Show InChI InChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,15H,10H2,(H,18,20)/t13-,15?,17-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 2.03E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activity at rat mGluR4 receptor expressed in HEK293 cells assessed as effect on thallium flux


J Med Chem 52: 4115-8 (2009)


Article DOI: 10.1021/jm9005065
BindingDB Entry DOI: 10.7270/Q2RJ4JHT
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4)


(Rattus norvegicus (Rat))
BDBM50263669
PNG
((1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetr...)
Show SMILES O=NC1[C@@H]2C[C@@]2(Oc2ccccc12)C(=O)Nc1ccccc1 |r|
Show InChI InChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,15H,10H2,(H,18,20)/t13-,15?,17-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 2.82E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization


J Med Chem 54: 1106-10 (2011)


Article DOI: 10.1021/jm101271s
BindingDB Entry DOI: 10.7270/Q27P90C1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50263669
PNG
((1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetr...)
Show SMILES O=NC1[C@@H]2C[C@@]2(Oc2ccccc12)C(=O)Nc1ccccc1 |r|
Show InChI InChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,15H,10H2,(H,18,20)/t13-,15?,17-/m0/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 3.10E+3n/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells assessed as potentiation of glutamate-induced calcium mobilization afte...


J Med Chem 54: 5070-81 (2011)


Article DOI: 10.1021/jm200290z
BindingDB Entry DOI: 10.7270/Q26110P5
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50263669
PNG
((1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetr...)
Show SMILES O=NC1[C@@H]2C[C@@]2(Oc2ccccc12)C(=O)Nc1ccccc1 |r|
Show InChI InChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,15H,10H2,(H,18,20)/t13-,15?,17-/m0/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 4.10E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activity at human mGluR4 expressed in CHO coexpressing Gqi5 assessed as potentiation of glutamate-induced calcium flux by fluorescence assay


Bioorg Med Chem Lett 18: 5626-30 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.087
BindingDB Entry DOI: 10.7270/Q24B327D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50263669
PNG
((1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetr...)
Show SMILES O=NC1[C@@H]2C[C@@]2(Oc2ccccc12)C(=O)Nc1ccccc1 |r|
Show InChI InChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,15H,10H2,(H,18,20)/t13-,15?,17-/m0/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 4.74E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization


J Med Chem 54: 1106-10 (2011)


Article DOI: 10.1021/jm101271s
BindingDB Entry DOI: 10.7270/Q27P90C1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4)


(Homo sapiens (Human))
BDBM50263669
PNG
((1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetr...)
Show SMILES O=NC1[C@@H]2C[C@@]2(Oc2ccccc12)C(=O)Nc1ccccc1 |r|
Show InChI InChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,15H,10H2,(H,18,20)/t13-,15?,17-/m0/s1
UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 5.00E+3n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...


Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair