Found 8 hits for monomerid = 50263814 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50263814
(CHEMBL4101216)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@H](C)O)[C@@H](C)CC |r| Show InChI InChI=1S/C77H113N23O16S2/c1-8-40(3)59-71(112)94-54-37-117-118-38-55(68(109)97-61(43(6)102)72(113)87-42(5)62(103)92-53(36-101)66(107)96-60(41(4)9-2)75(116)100-30-18-26-57(100)74(115)99-29-17-25-56(99)69(110)95-59)93-63(104)49(23-15-27-83-76(78)79)88-70(111)58(32-45-34-85-48-22-14-13-21-47(45)48)98(7)73(114)50(24-16-28-84-77(80)81)89-64(105)51(31-44-19-11-10-12-20-44)90-65(106)52(91-67(54)108)33-46-35-82-39-86-46/h10-14,19-22,34-35,39-43,49-61,85,101-102H,8-9,15-18,23-33,36-38H2,1-7H3,(H,82,86)(H,87,113)(H,88,111)(H,89,105)(H,90,106)(H,91,108)(H,92,103)(H,93,104)(H,94,112)(H,95,110)(H,96,107)(H,97,109)(H4,78,79,83)(H4,80,81,84)/t40-,41-,42-,43-,49-,50-,51+,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 3.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-alpha-MSH from human MC1R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50263814
(CHEMBL4101216)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@H](C)O)[C@@H](C)CC |r| Show InChI InChI=1S/C77H113N23O16S2/c1-8-40(3)59-71(112)94-54-37-117-118-38-55(68(109)97-61(43(6)102)72(113)87-42(5)62(103)92-53(36-101)66(107)96-60(41(4)9-2)75(116)100-30-18-26-57(100)74(115)99-29-17-25-56(99)69(110)95-59)93-63(104)49(23-15-27-83-76(78)79)88-70(111)58(32-45-34-85-48-22-14-13-21-47(45)48)98(7)73(114)50(24-16-28-84-77(80)81)89-64(105)51(31-44-19-11-10-12-20-44)90-65(106)52(91-67(54)108)33-46-35-82-39-86-46/h10-14,19-22,34-35,39-43,49-61,85,101-102H,8-9,15-18,23-33,36-38H2,1-7H3,(H,82,86)(H,87,113)(H,88,111)(H,89,105)(H,90,106)(H,91,108)(H,92,103)(H,93,104)(H,94,112)(H,95,110)(H,96,107)(H,97,109)(H4,78,79,83)(H4,80,81,84)/t40-,41-,42-,43-,49-,50-,51+,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-/m0/s1 | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 324 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50263814
(CHEMBL4101216)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@H](C)O)[C@@H](C)CC |r| Show InChI InChI=1S/C77H113N23O16S2/c1-8-40(3)59-71(112)94-54-37-117-118-38-55(68(109)97-61(43(6)102)72(113)87-42(5)62(103)92-53(36-101)66(107)96-60(41(4)9-2)75(116)100-30-18-26-57(100)74(115)99-29-17-25-56(99)69(110)95-59)93-63(104)49(23-15-27-83-76(78)79)88-70(111)58(32-45-34-85-48-22-14-13-21-47(45)48)98(7)73(114)50(24-16-28-84-77(80)81)89-64(105)51(31-44-19-11-10-12-20-44)90-65(106)52(91-67(54)108)33-46-35-82-39-86-46/h10-14,19-22,34-35,39-43,49-61,85,101-102H,8-9,15-18,23-33,36-38H2,1-7H3,(H,82,86)(H,87,113)(H,88,111)(H,89,105)(H,90,106)(H,91,108)(H,92,103)(H,93,104)(H,94,112)(H,95,110)(H,96,107)(H,97,109)(H4,78,79,83)(H4,80,81,84)/t40-,41-,42-,43-,49-,50-,51+,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 832 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-alpha-MSH from human MC4R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50263814
(CHEMBL4101216)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@H](C)O)[C@@H](C)CC |r| Show InChI InChI=1S/C77H113N23O16S2/c1-8-40(3)59-71(112)94-54-37-117-118-38-55(68(109)97-61(43(6)102)72(113)87-42(5)62(103)92-53(36-101)66(107)96-60(41(4)9-2)75(116)100-30-18-26-57(100)74(115)99-29-17-25-56(99)69(110)95-59)93-63(104)49(23-15-27-83-76(78)79)88-70(111)58(32-45-34-85-48-22-14-13-21-47(45)48)98(7)73(114)50(24-16-28-84-77(80)81)89-64(105)51(31-44-19-11-10-12-20-44)90-65(106)52(91-67(54)108)33-46-35-82-39-86-46/h10-14,19-22,34-35,39-43,49-61,85,101-102H,8-9,15-18,23-33,36-38H2,1-7H3,(H,82,86)(H,87,113)(H,88,111)(H,89,105)(H,90,106)(H,91,108)(H,92,103)(H,93,104)(H,94,112)(H,95,110)(H,96,107)(H,97,109)(H4,78,79,83)(H4,80,81,84)/t40-,41-,42-,43-,49-,50-,51+,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 331 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Agonist activity at human MC4R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50263814
(CHEMBL4101216)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@H](C)O)[C@@H](C)CC |r| Show InChI InChI=1S/C77H113N23O16S2/c1-8-40(3)59-71(112)94-54-37-117-118-38-55(68(109)97-61(43(6)102)72(113)87-42(5)62(103)92-53(36-101)66(107)96-60(41(4)9-2)75(116)100-30-18-26-57(100)74(115)99-29-17-25-56(99)69(110)95-59)93-63(104)49(23-15-27-83-76(78)79)88-70(111)58(32-45-34-85-48-22-14-13-21-47(45)48)98(7)73(114)50(24-16-28-84-77(80)81)89-64(105)51(31-44-19-11-10-12-20-44)90-65(106)52(91-67(54)108)33-46-35-82-39-86-46/h10-14,19-22,34-35,39-43,49-61,85,101-102H,8-9,15-18,23-33,36-38H2,1-7H3,(H,82,86)(H,87,113)(H,88,111)(H,89,105)(H,90,106)(H,91,108)(H,92,103)(H,93,104)(H,94,112)(H,95,110)(H,96,107)(H,97,109)(H4,78,79,83)(H4,80,81,84)/t40-,41-,42-,43-,49-,50-,51+,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 28 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Agonist activity at human MC4R expressed in high doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 15 mins by HT... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor (M4 and M5)
(Homo sapiens (Human)) | BDBM50263814
(CHEMBL4101216)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@H](C)O)[C@@H](C)CC |r| Show InChI InChI=1S/C77H113N23O16S2/c1-8-40(3)59-71(112)94-54-37-117-118-38-55(68(109)97-61(43(6)102)72(113)87-42(5)62(103)92-53(36-101)66(107)96-60(41(4)9-2)75(116)100-30-18-26-57(100)74(115)99-29-17-25-56(99)69(110)95-59)93-63(104)49(23-15-27-83-76(78)79)88-70(111)58(32-45-34-85-48-22-14-13-21-47(45)48)98(7)73(114)50(24-16-28-84-77(80)81)89-64(105)51(31-44-19-11-10-12-20-44)90-65(106)52(91-67(54)108)33-46-35-82-39-86-46/h10-14,19-22,34-35,39-43,49-61,85,101-102H,8-9,15-18,23-33,36-38H2,1-7H3,(H,82,86)(H,87,113)(H,88,111)(H,89,105)(H,90,106)(H,91,108)(H,92,103)(H,93,104)(H,94,112)(H,95,110)(H,96,107)(H,97,109)(H4,78,79,83)(H4,80,81,84)/t40-,41-,42-,43-,49-,50-,51+,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-/m0/s1 | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50263814
(CHEMBL4101216)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@H](C)O)[C@@H](C)CC |r| Show InChI InChI=1S/C77H113N23O16S2/c1-8-40(3)59-71(112)94-54-37-117-118-38-55(68(109)97-61(43(6)102)72(113)87-42(5)62(103)92-53(36-101)66(107)96-60(41(4)9-2)75(116)100-30-18-26-57(100)74(115)99-29-17-25-56(99)69(110)95-59)93-63(104)49(23-15-27-83-76(78)79)88-70(111)58(32-45-34-85-48-22-14-13-21-47(45)48)98(7)73(114)50(24-16-28-84-77(80)81)89-64(105)51(31-44-19-11-10-12-20-44)90-65(106)52(91-67(54)108)33-46-35-82-39-86-46/h10-14,19-22,34-35,39-43,49-61,85,101-102H,8-9,15-18,23-33,36-38H2,1-7H3,(H,82,86)(H,87,113)(H,88,111)(H,89,105)(H,90,106)(H,91,108)(H,92,103)(H,93,104)(H,94,112)(H,95,110)(H,96,107)(H,97,109)(H4,78,79,83)(H4,80,81,84)/t40-,41-,42-,43-,49-,50-,51+,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-/m0/s1 | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50263814
(CHEMBL4101216)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@H](C)O)[C@@H](C)CC |r| Show InChI InChI=1S/C77H113N23O16S2/c1-8-40(3)59-71(112)94-54-37-117-118-38-55(68(109)97-61(43(6)102)72(113)87-42(5)62(103)92-53(36-101)66(107)96-60(41(4)9-2)75(116)100-30-18-26-57(100)74(115)99-29-17-25-56(99)69(110)95-59)93-63(104)49(23-15-27-83-76(78)79)88-70(111)58(32-45-34-85-48-22-14-13-21-47(45)48)98(7)73(114)50(24-16-28-84-77(80)81)89-64(105)51(31-44-19-11-10-12-20-44)90-65(106)52(91-67(54)108)33-46-35-82-39-86-46/h10-14,19-22,34-35,39-43,49-61,85,101-102H,8-9,15-18,23-33,36-38H2,1-7H3,(H,82,86)(H,87,113)(H,88,111)(H,89,105)(H,90,106)(H,91,108)(H,92,103)(H,93,104)(H,94,112)(H,95,110)(H,96,107)(H,97,109)(H4,78,79,83)(H4,80,81,84)/t40-,41-,42-,43-,49-,50-,51+,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Agonist activity at human MC1R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |