Found 8 hits for monomerid = 50263818 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50263818
(CHEMBL4089162)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@H](C)O)[C@@H](C)CC |r| Show InChI InChI=1S/C78H115N23O16S2/c1-9-41(3)60-71(112)94-54-38-118-119-39-55(68(109)97-62(44(6)103)72(113)88-43(5)63(104)92-53(37-102)66(107)96-61(42(4)10-2)76(117)101-31-19-27-58(101)75(116)100-30-18-26-56(100)69(110)95-60)93-64(105)50(24-16-28-84-77(79)80)89-70(111)59(33-46-35-86-49-23-15-14-22-48(46)49)99(8)74(115)57(25-17-29-85-78(81)82)98(7)73(114)52(32-45-20-12-11-13-21-45)91-65(106)51(90-67(54)108)34-47-36-83-40-87-47/h11-15,20-23,35-36,40-44,50-62,86,102-103H,9-10,16-19,24-34,37-39H2,1-8H3,(H,83,87)(H,88,113)(H,89,111)(H,90,108)(H,91,106)(H,92,104)(H,93,105)(H,94,112)(H,95,110)(H,96,107)(H,97,109)(H4,79,80,84)(H4,81,82,85)/t41-,42-,43-,44-,50-,51-,52+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-alpha-MSH from human MC1R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50263818
(CHEMBL4089162)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@H](C)O)[C@@H](C)CC |r| Show InChI InChI=1S/C78H115N23O16S2/c1-9-41(3)60-71(112)94-54-38-118-119-39-55(68(109)97-62(44(6)103)72(113)88-43(5)63(104)92-53(37-102)66(107)96-61(42(4)10-2)76(117)101-31-19-27-58(101)75(116)100-30-18-26-56(100)69(110)95-60)93-64(105)50(24-16-28-84-77(79)80)89-70(111)59(33-46-35-86-49-23-15-14-22-48(46)49)99(8)74(115)57(25-17-29-85-78(81)82)98(7)73(114)52(32-45-20-12-11-13-21-45)91-65(106)51(90-67(54)108)34-47-36-83-40-87-47/h11-15,20-23,35-36,40-44,50-62,86,102-103H,9-10,16-19,24-34,37-39H2,1-8H3,(H,83,87)(H,88,113)(H,89,111)(H,90,108)(H,91,106)(H,92,104)(H,93,105)(H,94,112)(H,95,110)(H,96,107)(H,97,109)(H4,79,80,84)(H4,81,82,85)/t41-,42-,43-,44-,50-,51-,52+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-alpha-MSH from human MC4R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50263818
(CHEMBL4089162)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@H](C)O)[C@@H](C)CC |r| Show InChI InChI=1S/C78H115N23O16S2/c1-9-41(3)60-71(112)94-54-38-118-119-39-55(68(109)97-62(44(6)103)72(113)88-43(5)63(104)92-53(37-102)66(107)96-61(42(4)10-2)76(117)101-31-19-27-58(101)75(116)100-30-18-26-56(100)69(110)95-60)93-64(105)50(24-16-28-84-77(79)80)89-70(111)59(33-46-35-86-49-23-15-14-22-48(46)49)99(8)74(115)57(25-17-29-85-78(81)82)98(7)73(114)52(32-45-20-12-11-13-21-45)91-65(106)51(90-67(54)108)34-47-36-83-40-87-47/h11-15,20-23,35-36,40-44,50-62,86,102-103H,9-10,16-19,24-34,37-39H2,1-8H3,(H,83,87)(H,88,113)(H,89,111)(H,90,108)(H,91,106)(H,92,104)(H,93,105)(H,94,112)(H,95,110)(H,96,107)(H,97,109)(H4,79,80,84)(H4,81,82,85)/t41-,42-,43-,44-,50-,51-,52+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-/m0/s1 | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| <1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50263818
(CHEMBL4089162)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@H](C)O)[C@@H](C)CC |r| Show InChI InChI=1S/C78H115N23O16S2/c1-9-41(3)60-71(112)94-54-38-118-119-39-55(68(109)97-62(44(6)103)72(113)88-43(5)63(104)92-53(37-102)66(107)96-61(42(4)10-2)76(117)101-31-19-27-58(101)75(116)100-30-18-26-56(100)69(110)95-60)93-64(105)50(24-16-28-84-77(79)80)89-70(111)59(33-46-35-86-49-23-15-14-22-48(46)49)99(8)74(115)57(25-17-29-85-78(81)82)98(7)73(114)52(32-45-20-12-11-13-21-45)91-65(106)51(90-67(54)108)34-47-36-83-40-87-47/h11-15,20-23,35-36,40-44,50-62,86,102-103H,9-10,16-19,24-34,37-39H2,1-8H3,(H,83,87)(H,88,113)(H,89,111)(H,90,108)(H,91,106)(H,92,104)(H,93,105)(H,94,112)(H,95,110)(H,96,107)(H,97,109)(H4,79,80,84)(H4,81,82,85)/t41-,42-,43-,44-,50-,51-,52+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | <1.00E+3 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Agonist activity at human MC4R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor (M4 and M5)
(Homo sapiens (Human)) | BDBM50263818
(CHEMBL4089162)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@H](C)O)[C@@H](C)CC |r| Show InChI InChI=1S/C78H115N23O16S2/c1-9-41(3)60-71(112)94-54-38-118-119-39-55(68(109)97-62(44(6)103)72(113)88-43(5)63(104)92-53(37-102)66(107)96-61(42(4)10-2)76(117)101-31-19-27-58(101)75(116)100-30-18-26-56(100)69(110)95-60)93-64(105)50(24-16-28-84-77(79)80)89-70(111)59(33-46-35-86-49-23-15-14-22-48(46)49)99(8)74(115)57(25-17-29-85-78(81)82)98(7)73(114)52(32-45-20-12-11-13-21-45)91-65(106)51(90-67(54)108)34-47-36-83-40-87-47/h11-15,20-23,35-36,40-44,50-62,86,102-103H,9-10,16-19,24-34,37-39H2,1-8H3,(H,83,87)(H,88,113)(H,89,111)(H,90,108)(H,91,106)(H,92,104)(H,93,105)(H,94,112)(H,95,110)(H,96,107)(H,97,109)(H4,79,80,84)(H4,81,82,85)/t41-,42-,43-,44-,50-,51-,52+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-/m0/s1 | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 813 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50263818
(CHEMBL4089162)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@H](C)O)[C@@H](C)CC |r| Show InChI InChI=1S/C78H115N23O16S2/c1-9-41(3)60-71(112)94-54-38-118-119-39-55(68(109)97-62(44(6)103)72(113)88-43(5)63(104)92-53(37-102)66(107)96-61(42(4)10-2)76(117)101-31-19-27-58(101)75(116)100-30-18-26-56(100)69(110)95-60)93-64(105)50(24-16-28-84-77(79)80)89-70(111)59(33-46-35-86-49-23-15-14-22-48(46)49)99(8)74(115)57(25-17-29-85-78(81)82)98(7)73(114)52(32-45-20-12-11-13-21-45)91-65(106)51(90-67(54)108)34-47-36-83-40-87-47/h11-15,20-23,35-36,40-44,50-62,86,102-103H,9-10,16-19,24-34,37-39H2,1-8H3,(H,83,87)(H,88,113)(H,89,111)(H,90,108)(H,91,106)(H,92,104)(H,93,105)(H,94,112)(H,95,110)(H,96,107)(H,97,109)(H4,79,80,84)(H4,81,82,85)/t41-,42-,43-,44-,50-,51-,52+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Agonist activity at human MC4R expressed in high doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 15 mins by HT... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50263818
(CHEMBL4089162)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@H](C)O)[C@@H](C)CC |r| Show InChI InChI=1S/C78H115N23O16S2/c1-9-41(3)60-71(112)94-54-38-118-119-39-55(68(109)97-62(44(6)103)72(113)88-43(5)63(104)92-53(37-102)66(107)96-61(42(4)10-2)76(117)101-31-19-27-58(101)75(116)100-30-18-26-56(100)69(110)95-60)93-64(105)50(24-16-28-84-77(79)80)89-70(111)59(33-46-35-86-49-23-15-14-22-48(46)49)99(8)74(115)57(25-17-29-85-78(81)82)98(7)73(114)52(32-45-20-12-11-13-21-45)91-65(106)51(90-67(54)108)34-47-36-83-40-87-47/h11-15,20-23,35-36,40-44,50-62,86,102-103H,9-10,16-19,24-34,37-39H2,1-8H3,(H,83,87)(H,88,113)(H,89,111)(H,90,108)(H,91,106)(H,92,104)(H,93,105)(H,94,112)(H,95,110)(H,96,107)(H,97,109)(H4,79,80,84)(H4,81,82,85)/t41-,42-,43-,44-,50-,51-,52+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-/m0/s1 | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 309 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50263818
(CHEMBL4089162)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N(C)[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@H](C)O)[C@@H](C)CC |r| Show InChI InChI=1S/C78H115N23O16S2/c1-9-41(3)60-71(112)94-54-38-118-119-39-55(68(109)97-62(44(6)103)72(113)88-43(5)63(104)92-53(37-102)66(107)96-61(42(4)10-2)76(117)101-31-19-27-58(101)75(116)100-30-18-26-56(100)69(110)95-60)93-64(105)50(24-16-28-84-77(79)80)89-70(111)59(33-46-35-86-49-23-15-14-22-48(46)49)99(8)74(115)57(25-17-29-85-78(81)82)98(7)73(114)52(32-45-20-12-11-13-21-45)91-65(106)51(90-67(54)108)34-47-36-83-40-87-47/h11-15,20-23,35-36,40-44,50-62,86,102-103H,9-10,16-19,24-34,37-39H2,1-8H3,(H,83,87)(H,88,113)(H,89,111)(H,90,108)(H,91,106)(H,92,104)(H,93,105)(H,94,112)(H,95,110)(H,96,107)(H,97,109)(H4,79,80,84)(H4,81,82,85)/t41-,42-,43-,44-,50-,51-,52+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 0.741 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Agonist activity at human MC1R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |