Found 8 hits for monomerid = 50263821 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50263821
(CHEMBL4080223)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@@H](C)O |r| Show InChI InChI=1S/C80H109N23O17S2/c1-5-43(2)64-75(117)98-57-40-121-122-41-58(97-67(109)51(24-14-28-86-79(81)82)91-62(105)39-89-66(108)54(36-63(106)107)94-72(114)59-26-16-30-102(59)76(118)55(95-70(57)112)33-46-20-10-7-11-21-46)71(113)100-65(44(3)104)78(120)101(4)61(35-48-38-85-42-90-48)74(116)93-53(32-45-18-8-6-9-19-45)69(111)92-52(25-15-29-87-80(83)84)68(110)96-56(34-47-37-88-50-23-13-12-22-49(47)50)77(119)103-31-17-27-60(103)73(115)99-64/h6-13,18-23,37-38,42-44,51-61,64-65,88,104H,5,14-17,24-36,39-41H2,1-4H3,(H,85,90)(H,89,108)(H,91,105)(H,92,111)(H,93,116)(H,94,114)(H,95,112)(H,96,110)(H,97,109)(H,98,117)(H,99,115)(H,100,113)(H,106,107)(H4,81,82,86)(H4,83,84,87)/t43-,44+,51-,52-,53+,54-,55-,56-,57-,58-,59-,60-,61-,64-,65-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 4.68E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-alpha-MSH from human MC1R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50263821
(CHEMBL4080223)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@@H](C)O |r| Show InChI InChI=1S/C80H109N23O17S2/c1-5-43(2)64-75(117)98-57-40-121-122-41-58(97-67(109)51(24-14-28-86-79(81)82)91-62(105)39-89-66(108)54(36-63(106)107)94-72(114)59-26-16-30-102(59)76(118)55(95-70(57)112)33-46-20-10-7-11-21-46)71(113)100-65(44(3)104)78(120)101(4)61(35-48-38-85-42-90-48)74(116)93-53(32-45-18-8-6-9-19-45)69(111)92-52(25-15-29-87-80(83)84)68(110)96-56(34-47-37-88-50-23-13-12-22-49(47)50)77(119)103-31-17-27-60(103)73(115)99-64/h6-13,18-23,37-38,42-44,51-61,64-65,88,104H,5,14-17,24-36,39-41H2,1-4H3,(H,85,90)(H,89,108)(H,91,105)(H,92,111)(H,93,116)(H,94,114)(H,95,112)(H,96,110)(H,97,109)(H,98,117)(H,99,115)(H,100,113)(H,106,107)(H4,81,82,86)(H4,83,84,87)/t43-,44+,51-,52-,53+,54-,55-,56-,57-,58-,59-,60-,61-,64-,65-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 6.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-alpha-MSH from human MC4R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50263821
(CHEMBL4080223)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@@H](C)O |r| Show InChI InChI=1S/C80H109N23O17S2/c1-5-43(2)64-75(117)98-57-40-121-122-41-58(97-67(109)51(24-14-28-86-79(81)82)91-62(105)39-89-66(108)54(36-63(106)107)94-72(114)59-26-16-30-102(59)76(118)55(95-70(57)112)33-46-20-10-7-11-21-46)71(113)100-65(44(3)104)78(120)101(4)61(35-48-38-85-42-90-48)74(116)93-53(32-45-18-8-6-9-19-45)69(111)92-52(25-15-29-87-80(83)84)68(110)96-56(34-47-37-88-50-23-13-12-22-49(47)50)77(119)103-31-17-27-60(103)73(115)99-64/h6-13,18-23,37-38,42-44,51-61,64-65,88,104H,5,14-17,24-36,39-41H2,1-4H3,(H,85,90)(H,89,108)(H,91,105)(H,92,111)(H,93,116)(H,94,114)(H,95,112)(H,96,110)(H,97,109)(H,98,117)(H,99,115)(H,100,113)(H,106,107)(H4,81,82,86)(H4,83,84,87)/t43-,44+,51-,52-,53+,54-,55-,56-,57-,58-,59-,60-,61-,64-,65-/m0/s1 | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 3.89E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor (M4 and M5)
(Homo sapiens (Human)) | BDBM50263821
(CHEMBL4080223)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@@H](C)O |r| Show InChI InChI=1S/C80H109N23O17S2/c1-5-43(2)64-75(117)98-57-40-121-122-41-58(97-67(109)51(24-14-28-86-79(81)82)91-62(105)39-89-66(108)54(36-63(106)107)94-72(114)59-26-16-30-102(59)76(118)55(95-70(57)112)33-46-20-10-7-11-21-46)71(113)100-65(44(3)104)78(120)101(4)61(35-48-38-85-42-90-48)74(116)93-53(32-45-18-8-6-9-19-45)69(111)92-52(25-15-29-87-80(83)84)68(110)96-56(34-47-37-88-50-23-13-12-22-49(47)50)77(119)103-31-17-27-60(103)73(115)99-64/h6-13,18-23,37-38,42-44,51-61,64-65,88,104H,5,14-17,24-36,39-41H2,1-4H3,(H,85,90)(H,89,108)(H,91,105)(H,92,111)(H,93,116)(H,94,114)(H,95,112)(H,96,110)(H,97,109)(H,98,117)(H,99,115)(H,100,113)(H,106,107)(H4,81,82,86)(H4,83,84,87)/t43-,44+,51-,52-,53+,54-,55-,56-,57-,58-,59-,60-,61-,64-,65-/m0/s1 | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.12E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50263821
(CHEMBL4080223)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@@H](C)O |r| Show InChI InChI=1S/C80H109N23O17S2/c1-5-43(2)64-75(117)98-57-40-121-122-41-58(97-67(109)51(24-14-28-86-79(81)82)91-62(105)39-89-66(108)54(36-63(106)107)94-72(114)59-26-16-30-102(59)76(118)55(95-70(57)112)33-46-20-10-7-11-21-46)71(113)100-65(44(3)104)78(120)101(4)61(35-48-38-85-42-90-48)74(116)93-53(32-45-18-8-6-9-19-45)69(111)92-52(25-15-29-87-80(83)84)68(110)96-56(34-47-37-88-50-23-13-12-22-49(47)50)77(119)103-31-17-27-60(103)73(115)99-64/h6-13,18-23,37-38,42-44,51-61,64-65,88,104H,5,14-17,24-36,39-41H2,1-4H3,(H,85,90)(H,89,108)(H,91,105)(H,92,111)(H,93,116)(H,94,114)(H,95,112)(H,96,110)(H,97,109)(H,98,117)(H,99,115)(H,100,113)(H,106,107)(H4,81,82,86)(H4,83,84,87)/t43-,44+,51-,52-,53+,54-,55-,56-,57-,58-,59-,60-,61-,64-,65-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.05E+3 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Agonist activity at human MC4R expressed in high doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 15 mins by HT... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50263821
(CHEMBL4080223)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@@H](C)O |r| Show InChI InChI=1S/C80H109N23O17S2/c1-5-43(2)64-75(117)98-57-40-121-122-41-58(97-67(109)51(24-14-28-86-79(81)82)91-62(105)39-89-66(108)54(36-63(106)107)94-72(114)59-26-16-30-102(59)76(118)55(95-70(57)112)33-46-20-10-7-11-21-46)71(113)100-65(44(3)104)78(120)101(4)61(35-48-38-85-42-90-48)74(116)93-53(32-45-18-8-6-9-19-45)69(111)92-52(25-15-29-87-80(83)84)68(110)96-56(34-47-37-88-50-23-13-12-22-49(47)50)77(119)103-31-17-27-60(103)73(115)99-64/h6-13,18-23,37-38,42-44,51-61,64-65,88,104H,5,14-17,24-36,39-41H2,1-4H3,(H,85,90)(H,89,108)(H,91,105)(H,92,111)(H,93,116)(H,94,114)(H,95,112)(H,96,110)(H,97,109)(H,98,117)(H,99,115)(H,100,113)(H,106,107)(H4,81,82,86)(H4,83,84,87)/t43-,44+,51-,52-,53+,54-,55-,56-,57-,58-,59-,60-,61-,64-,65-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.07E+4 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Agonist activity at human MC4R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50263821
(CHEMBL4080223)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@@H](C)O |r| Show InChI InChI=1S/C80H109N23O17S2/c1-5-43(2)64-75(117)98-57-40-121-122-41-58(97-67(109)51(24-14-28-86-79(81)82)91-62(105)39-89-66(108)54(36-63(106)107)94-72(114)59-26-16-30-102(59)76(118)55(95-70(57)112)33-46-20-10-7-11-21-46)71(113)100-65(44(3)104)78(120)101(4)61(35-48-38-85-42-90-48)74(116)93-53(32-45-18-8-6-9-19-45)69(111)92-52(25-15-29-87-80(83)84)68(110)96-56(34-47-37-88-50-23-13-12-22-49(47)50)77(119)103-31-17-27-60(103)73(115)99-64/h6-13,18-23,37-38,42-44,51-61,64-65,88,104H,5,14-17,24-36,39-41H2,1-4H3,(H,85,90)(H,89,108)(H,91,105)(H,92,111)(H,93,116)(H,94,114)(H,95,112)(H,96,110)(H,97,109)(H,98,117)(H,99,115)(H,100,113)(H,106,107)(H4,81,82,86)(H4,83,84,87)/t43-,44+,51-,52-,53+,54-,55-,56-,57-,58-,59-,60-,61-,64-,65-/m0/s1 | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 7.41E+3 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50263821
(CHEMBL4080223)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@@H](C)O |r| Show InChI InChI=1S/C80H109N23O17S2/c1-5-43(2)64-75(117)98-57-40-121-122-41-58(97-67(109)51(24-14-28-86-79(81)82)91-62(105)39-89-66(108)54(36-63(106)107)94-72(114)59-26-16-30-102(59)76(118)55(95-70(57)112)33-46-20-10-7-11-21-46)71(113)100-65(44(3)104)78(120)101(4)61(35-48-38-85-42-90-48)74(116)93-53(32-45-18-8-6-9-19-45)69(111)92-52(25-15-29-87-80(83)84)68(110)96-56(34-47-37-88-50-23-13-12-22-49(47)50)77(119)103-31-17-27-60(103)73(115)99-64/h6-13,18-23,37-38,42-44,51-61,64-65,88,104H,5,14-17,24-36,39-41H2,1-4H3,(H,85,90)(H,89,108)(H,91,105)(H,92,111)(H,93,116)(H,94,114)(H,95,112)(H,96,110)(H,97,109)(H,98,117)(H,99,115)(H,100,113)(H,106,107)(H4,81,82,86)(H4,83,84,87)/t43-,44+,51-,52-,53+,54-,55-,56-,57-,58-,59-,60-,61-,64-,65-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.32E+3 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Agonist activity at human MC1R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |