Found 8 hits for monomerid = 50263830 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50263830
(CHEMBL4064433)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@@H](C)O |r| Show InChI InChI=1S/C81H111N23O17S2/c1-6-44(2)65-75(117)98-57-41-122-123-42-58(97-68(110)52(25-15-29-87-80(82)83)92-63(106)40-90-67(109)53(37-64(107)108)93-72(114)60-27-17-31-103(60)77(119)55(94-69(57)111)34-47-21-11-8-12-22-47)70(112)100-66(45(3)105)79(121)102(5)62(36-49-39-86-43-91-49)74(116)95-54(33-46-19-9-7-10-20-46)76(118)101(4)59(26-16-30-88-81(84)85)71(113)96-56(35-48-38-89-51-24-14-13-23-50(48)51)78(120)104-32-18-28-61(104)73(115)99-65/h7-14,19-24,38-39,43-45,52-62,65-66,89,105H,6,15-18,25-37,40-42H2,1-5H3,(H,86,91)(H,90,109)(H,92,106)(H,93,114)(H,94,111)(H,95,116)(H,96,113)(H,97,110)(H,98,117)(H,99,115)(H,100,112)(H,107,108)(H4,82,83,87)(H4,84,85,88)/t44-,45+,52-,53-,54+,55-,56-,57-,58-,59-,60-,61-,62-,65-,66-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid UniChem
Patents
| Article PubMed
| 1.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-alpha-MSH from human MC1R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50263830
(CHEMBL4064433)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@@H](C)O |r| Show InChI InChI=1S/C81H111N23O17S2/c1-6-44(2)65-75(117)98-57-41-122-123-42-58(97-68(110)52(25-15-29-87-80(82)83)92-63(106)40-90-67(109)53(37-64(107)108)93-72(114)60-27-17-31-103(60)77(119)55(94-69(57)111)34-47-21-11-8-12-22-47)70(112)100-66(45(3)105)79(121)102(5)62(36-49-39-86-43-91-49)74(116)95-54(33-46-19-9-7-10-20-46)76(118)101(4)59(26-16-30-88-81(84)85)71(113)96-56(35-48-38-89-51-24-14-13-23-50(48)51)78(120)104-32-18-28-61(104)73(115)99-65/h7-14,19-24,38-39,43-45,52-62,65-66,89,105H,6,15-18,25-37,40-42H2,1-5H3,(H,86,91)(H,90,109)(H,92,106)(H,93,114)(H,94,111)(H,95,116)(H,96,113)(H,97,110)(H,98,117)(H,99,115)(H,100,112)(H,107,108)(H4,82,83,87)(H4,84,85,88)/t44-,45+,52-,53-,54+,55-,56-,57-,58-,59-,60-,61-,62-,65-,66-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid UniChem
Patents
| Article PubMed
| 6.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-alpha-MSH from human MC4R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50263830
(CHEMBL4064433)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@@H](C)O |r| Show InChI InChI=1S/C81H111N23O17S2/c1-6-44(2)65-75(117)98-57-41-122-123-42-58(97-68(110)52(25-15-29-87-80(82)83)92-63(106)40-90-67(109)53(37-64(107)108)93-72(114)60-27-17-31-103(60)77(119)55(94-69(57)111)34-47-21-11-8-12-22-47)70(112)100-66(45(3)105)79(121)102(5)62(36-49-39-86-43-91-49)74(116)95-54(33-46-19-9-7-10-20-46)76(118)101(4)59(26-16-30-88-81(84)85)71(113)96-56(35-48-38-89-51-24-14-13-23-50(48)51)78(120)104-32-18-28-61(104)73(115)99-65/h7-14,19-24,38-39,43-45,52-62,65-66,89,105H,6,15-18,25-37,40-42H2,1-5H3,(H,86,91)(H,90,109)(H,92,106)(H,93,114)(H,94,111)(H,95,116)(H,96,113)(H,97,110)(H,98,117)(H,99,115)(H,100,112)(H,107,108)(H4,82,83,87)(H4,84,85,88)/t44-,45+,52-,53-,54+,55-,56-,57-,58-,59-,60-,61-,62-,65-,66-/m0/s1 | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid UniChem
Patents
| Article PubMed
| 2.45E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-alpha-MSH from human MC3R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50263830
(CHEMBL4064433)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@@H](C)O |r| Show InChI InChI=1S/C81H111N23O17S2/c1-6-44(2)65-75(117)98-57-41-122-123-42-58(97-68(110)52(25-15-29-87-80(82)83)92-63(106)40-90-67(109)53(37-64(107)108)93-72(114)60-27-17-31-103(60)77(119)55(94-69(57)111)34-47-21-11-8-12-22-47)70(112)100-66(45(3)105)79(121)102(5)62(36-49-39-86-43-91-49)74(116)95-54(33-46-19-9-7-10-20-46)76(118)101(4)59(26-16-30-88-81(84)85)71(113)96-56(35-48-38-89-51-24-14-13-23-50(48)51)78(120)104-32-18-28-61(104)73(115)99-65/h7-14,19-24,38-39,43-45,52-62,65-66,89,105H,6,15-18,25-37,40-42H2,1-5H3,(H,86,91)(H,90,109)(H,92,106)(H,93,114)(H,94,111)(H,95,116)(H,96,113)(H,97,110)(H,98,117)(H,99,115)(H,100,112)(H,107,108)(H4,82,83,87)(H4,84,85,88)/t44-,45+,52-,53-,54+,55-,56-,57-,58-,59-,60-,61-,62-,65-,66-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | n/a | 389 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Agonist activity at human MC1R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50263830
(CHEMBL4064433)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@@H](C)O |r| Show InChI InChI=1S/C81H111N23O17S2/c1-6-44(2)65-75(117)98-57-41-122-123-42-58(97-68(110)52(25-15-29-87-80(82)83)92-63(106)40-90-67(109)53(37-64(107)108)93-72(114)60-27-17-31-103(60)77(119)55(94-69(57)111)34-47-21-11-8-12-22-47)70(112)100-66(45(3)105)79(121)102(5)62(36-49-39-86-43-91-49)74(116)95-54(33-46-19-9-7-10-20-46)76(118)101(4)59(26-16-30-88-81(84)85)71(113)96-56(35-48-38-89-51-24-14-13-23-50(48)51)78(120)104-32-18-28-61(104)73(115)99-65/h7-14,19-24,38-39,43-45,52-62,65-66,89,105H,6,15-18,25-37,40-42H2,1-5H3,(H,86,91)(H,90,109)(H,92,106)(H,93,114)(H,94,111)(H,95,116)(H,96,113)(H,97,110)(H,98,117)(H,99,115)(H,100,112)(H,107,108)(H4,82,83,87)(H4,84,85,88)/t44-,45+,52-,53-,54+,55-,56-,57-,58-,59-,60-,61-,62-,65-,66-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | n/a | 525 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Agonist activity at human MC4R expressed in high doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 15 mins by HT... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50263830
(CHEMBL4064433)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@@H](C)O |r| Show InChI InChI=1S/C81H111N23O17S2/c1-6-44(2)65-75(117)98-57-41-122-123-42-58(97-68(110)52(25-15-29-87-80(82)83)92-63(106)40-90-67(109)53(37-64(107)108)93-72(114)60-27-17-31-103(60)77(119)55(94-69(57)111)34-47-21-11-8-12-22-47)70(112)100-66(45(3)105)79(121)102(5)62(36-49-39-86-43-91-49)74(116)95-54(33-46-19-9-7-10-20-46)76(118)101(4)59(26-16-30-88-81(84)85)71(113)96-56(35-48-38-89-51-24-14-13-23-50(48)51)78(120)104-32-18-28-61(104)73(115)99-65/h7-14,19-24,38-39,43-45,52-62,65-66,89,105H,6,15-18,25-37,40-42H2,1-5H3,(H,86,91)(H,90,109)(H,92,106)(H,93,114)(H,94,111)(H,95,116)(H,96,113)(H,97,110)(H,98,117)(H,99,115)(H,100,112)(H,107,108)(H4,82,83,87)(H4,84,85,88)/t44-,45+,52-,53-,54+,55-,56-,57-,58-,59-,60-,61-,62-,65-,66-/m0/s1 | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | n/a | 5.37E+3 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Agonist activity at human MC3R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50263830
(CHEMBL4064433)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@@H](C)O |r| Show InChI InChI=1S/C81H111N23O17S2/c1-6-44(2)65-75(117)98-57-41-122-123-42-58(97-68(110)52(25-15-29-87-80(82)83)92-63(106)40-90-67(109)53(37-64(107)108)93-72(114)60-27-17-31-103(60)77(119)55(94-69(57)111)34-47-21-11-8-12-22-47)70(112)100-66(45(3)105)79(121)102(5)62(36-49-39-86-43-91-49)74(116)95-54(33-46-19-9-7-10-20-46)76(118)101(4)59(26-16-30-88-81(84)85)71(113)96-56(35-48-38-89-51-24-14-13-23-50(48)51)78(120)104-32-18-28-61(104)73(115)99-65/h7-14,19-24,38-39,43-45,52-62,65-66,89,105H,6,15-18,25-37,40-42H2,1-5H3,(H,86,91)(H,90,109)(H,92,106)(H,93,114)(H,94,111)(H,95,116)(H,96,113)(H,97,110)(H,98,117)(H,99,115)(H,100,112)(H,107,108)(H4,82,83,87)(H4,84,85,88)/t44-,45+,52-,53-,54+,55-,56-,57-,58-,59-,60-,61-,62-,65-,66-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | n/a | n/a | 9.12E+3 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Agonist activity at human MC4R expressed in low doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 45 mins by HTR... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |
Melanocortin receptor (M4 and M5)
(Homo sapiens (Human)) | BDBM50263830
(CHEMBL4064433)Show SMILES CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)N(C)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)N(C)C(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N2)[C@@H](C)O |r| Show InChI InChI=1S/C81H111N23O17S2/c1-6-44(2)65-75(117)98-57-41-122-123-42-58(97-68(110)52(25-15-29-87-80(82)83)92-63(106)40-90-67(109)53(37-64(107)108)93-72(114)60-27-17-31-103(60)77(119)55(94-69(57)111)34-47-21-11-8-12-22-47)70(112)100-66(45(3)105)79(121)102(5)62(36-49-39-86-43-91-49)74(116)95-54(33-46-19-9-7-10-20-46)76(118)101(4)59(26-16-30-88-81(84)85)71(113)96-56(35-48-38-89-51-24-14-13-23-50(48)51)78(120)104-32-18-28-61(104)73(115)99-65/h7-14,19-24,38-39,43-45,52-62,65-66,89,105H,6,15-18,25-37,40-42H2,1-5H3,(H,86,91)(H,90,109)(H,92,106)(H,93,114)(H,94,111)(H,95,116)(H,96,113)(H,97,110)(H,98,117)(H,99,115)(H,100,112)(H,107,108)(H4,82,83,87)(H4,84,85,88)/t44-,45+,52-,53-,54+,55-,56-,57-,58-,59-,60-,61-,62-,65-,66-/m0/s1 | UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 1.62E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description Displacement of [125I]-NDP-alpha-MSH from human MC5R LBD expressed in HEK293 cell membranes incubated for 16 to 23 hrs in dark by scintillation proxi... |
J Med Chem 61: 3674-3684 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00170 BindingDB Entry DOI: 10.7270/Q2736TCZ |
More data for this Ligand-Target Pair | |