BDBM50263896 CHEMBL501876::N-methyl-N-(2-(piperidin-1-yl)ethyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

SMILES: CN(CCN1CCCCC1)C(=O)N1CCc2ccccc2C1

InChI Key: InChIKey=RFJSMYGMPMODLQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50263896   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50263896 (CHEMBL501876 | N-methyl-N-(2-(piperidin-1-yl)ethyl...) Show SMILES CN(CCN1CCCCC1)C(=O)N1CCc2ccccc2C1 Show InChI InChI=1S/C18H27N3O/c1-19(13-14-20-10-5-2-6-11-20)18(22)21-12-9-16-7-3-4-8-17(16)15-21/h3-4,7-8H,2,5-6,9-15H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	680	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS binding				Bioorg Med Chem Lett 18: 5101-6 (2008) Article DOI: 10.1016/j.bmcl.2008.07.125 BindingDB Entry DOI: 10.7270/Q2PC3268
					More data for this Ligand-Target Pair