BDBM50263948 4-cyano-N-methyl-4-phenyl-N-(2-(piperidin-1-yl)ethyl)piperidine-1-carboxamide::CHEMBL448362

SMILES: CN(CCN1CCCCC1)C(=O)N1CCC(CC1)(C#N)c1ccccc1

InChI Key: InChIKey=CXGKOSAZNSEUKH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50263948   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50263948 (4-cyano-N-methyl-4-phenyl-N-(2-(piperidin-1-yl)eth...) Show SMILES CN(CCN1CCCCC1)C(=O)N1CCC(CC1)(C#N)c1ccccc1 Show InChI InChI=1S/C21H30N4O/c1-23(16-17-24-12-6-3-7-13-24)20(26)25-14-10-21(18-22,11-15-25)19-8-4-2-5-9-19/h2,4-5,8-9H,3,6-7,10-17H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	267	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS binding				Bioorg Med Chem Lett 18: 5101-6 (2008) Article DOI: 10.1016/j.bmcl.2008.07.125 BindingDB Entry DOI: 10.7270/Q2PC3268
					More data for this Ligand-Target Pair