BDBM50264068 CHEMBL504191::N-methyl-3-oxo-N-[2-(piperidin-1-yl)ethyl]-2,3-dihydrospiro[isoindole-1,4'-piperidine]-1'-carboxamide

SMILES: CN(CCN1CCCCC1)C(=O)N1CCC2(CC1)NC(=O)c1ccccc21

InChI Key: InChIKey=RCMWUIMATFNCDT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50264068   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50264068 (CHEMBL504191 | N-methyl-3-oxo-N-[2-(piperidin-1-yl...) Show SMILES CN(CCN1CCCCC1)C(=O)N1CCC2(CC1)NC(=O)c1ccccc21 Show InChI InChI=1S/C21H30N4O2/c1-23(15-16-24-11-5-2-6-12-24)20(27)25-13-9-21(10-14-25)18-8-4-3-7-17(18)19(26)22-21/h3-4,7-8H,2,5-6,9-16H2,1H3,(H,22,26)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Inverse agonist activity at human cloned histamine H3 receptor assessed as inhibition of (R)-alpha-methylhistamine-induced [35S]GTPgammaS binding				Bioorg Med Chem Lett 18: 5101-6 (2008) Article DOI: 10.1016/j.bmcl.2008.07.125 BindingDB Entry DOI: 10.7270/Q2PC3268
					More data for this Ligand-Target Pair