BindingDB PrimarySearch

BDBM50264389 6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)phenylamino)benzo[d]isoxazole-7-carboxamide::6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide::CHEMBL491429

SMILES: FC(F)(F)c1cccc(Nc2noc3c(C(=O)Nc4cncnc4)c(Cl)ccc23)c1

InChI Key: InChIKey=FEGRQUWSKADGSP-UHFFFAOYSA-N

Data: 7 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50264389
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50264389 (6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of c-kit (unknown origin)				Bioorg Med Chem Lett 18: 5115-7 (2008) Article DOI: 10.1016/j.bmcl.2008.07.111 BindingDB Entry DOI: 10.7270/Q2B56JJH
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50264389 (6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	353	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of KDR (unknown origin)				Bioorg Med Chem Lett 18: 5115-7 (2008) Article DOI: 10.1016/j.bmcl.2008.07.111 BindingDB Entry DOI: 10.7270/Q2B56JJH
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50264389 (6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2 (unknown origin)				Bioorg Med Chem Lett 18: 5115-7 (2008) Article DOI: 10.1016/j.bmcl.2008.07.111 BindingDB Entry DOI: 10.7270/Q2B56JJH
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50264389 (6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of PDGFRalpha (unknown origin)				Bioorg Med Chem Lett 18: 5115-7 (2008) Article DOI: 10.1016/j.bmcl.2008.07.111 BindingDB Entry DOI: 10.7270/Q2B56JJH
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50264389 (6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Lck (unknown origin)				Bioorg Med Chem Lett 18: 5115-7 (2008) Article DOI: 10.1016/j.bmcl.2008.07.111 BindingDB Entry DOI: 10.7270/Q2B56JJH
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM50264389 (6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of cFMS (unknown origin)				Bioorg Med Chem Lett 18: 5115-7 (2008) Article DOI: 10.1016/j.bmcl.2008.07.111 BindingDB Entry DOI: 10.7270/Q2B56JJH
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50264389 (6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	117	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Src (unknown origin)				Bioorg Med Chem Lett 18: 5115-7 (2008) Article DOI: 10.1016/j.bmcl.2008.07.111 BindingDB Entry DOI: 10.7270/Q2B56JJH
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair