BDBM50264800 3-(2-chloro-6-fluorophenyl)-5-(1-ethyl-2-(piperidin-4-yl)-1H-imidazol-5-yl)isoxazole::CHEMBL522610

SMILES: CCn1c(cnc1C1CCNCC1)-c1cc(no1)-c1c(F)cccc1Cl

InChI Key: InChIKey=REISQSFVUDAFPJ-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50264800   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuronal acetylcholine receptor subunit alpha-4 (Homo sapiens (Human))	BDBM50264800 (3-(2-chloro-6-fluorophenyl)-5-(1-ethyl-2-(piperidi...) Show SMILES CCn1c(cnc1C1CCNCC1)-c1cc(no1)-c1c(F)cccc1Cl Show InChI InChI=1S/C19H20ClFN4O/c1-2-25-16(11-23-19(25)12-6-8-22-9-7-12)17-10-15(24-26-17)18-13(20)4-3-5-14(18)21/h3-5,10-12,22H,2,6-9H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced current				Bioorg Med Chem Lett 18: 5209-12 (2008) Article DOI: 10.1016/j.bmcl.2008.08.080 BindingDB Entry DOI: 10.7270/Q2SX6D26
					More data for this Ligand-Target Pair