BDBM50264801 3-(2-chloro-6-fluorophenyl)-5-(2-(4-fluoropiperidin-4-yl)-1-methyl-1H-imidazol-5-yl)isoxazole::CHEMBL490430

SMILES: Cn1c(cnc1C1(F)CCNCC1)-c1cc(no1)-c1c(F)cccc1Cl

InChI Key: InChIKey=BQFJTJDULYXNJI-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50264801   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuronal acetylcholine receptor subunit alpha-4 (Homo sapiens (Human))	BDBM50264801 (3-(2-chloro-6-fluorophenyl)-5-(2-(4-fluoropiperidi...) Show SMILES Cn1c(cnc1C1(F)CCNCC1)-c1cc(no1)-c1c(F)cccc1Cl Show InChI InChI=1S/C18H17ClF2N4O/c1-25-14(10-23-17(25)18(21)5-7-22-8-6-18)15-9-13(24-26-15)16-11(19)3-2-4-12(16)20/h2-4,9-10,22H,5-8H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	34	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced current				Bioorg Med Chem Lett 18: 5209-12 (2008) Article DOI: 10.1016/j.bmcl.2008.08.080 BindingDB Entry DOI: 10.7270/Q2SX6D26
					More data for this Ligand-Target Pair