BDBM50264882 CHEMBL497990::N-((3-(2-chlorophenyl)isoxazol-5-yl)methyl)-N-methylpiperidine-4-carboxamide

SMILES: CN(Cc1cc(no1)-c1ccccc1Cl)C(=O)C1CCNCC1

InChI Key: InChIKey=CYVLVDMCSIBANZ-UHFFFAOYSA-N

Data: 3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50264882   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuronal acetylcholine receptor subunit alpha-4 (Homo sapiens (Human))	BDBM50264882 (CHEMBL497990 | N-((3-(2-chlorophenyl)isoxazol-5-yl...) Show SMILES CN(Cc1cc(no1)-c1ccccc1Cl)C(=O)C1CCNCC1 Show InChI InChI=1S/C17H20ClN3O2/c1-21(17(22)12-6-8-19-9-7-12)11-13-10-16(20-23-13)14-4-2-3-5-15(14)18/h2-5,10,12,19H,6-9,11H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	350	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Activation of human alpha4beta2 nAChR assessed as potentiation of submaximal response to nicotine induced current				Bioorg Med Chem Lett 18: 5209-12 (2008) Article DOI: 10.1016/j.bmcl.2008.08.080 BindingDB Entry DOI: 10.7270/Q2SX6D26
					More data for this Ligand-Target Pair
Cholinergic, Nicotinic Alpha3Beta2 (Homo sapiens (Human))	BDBM50264882 (CHEMBL497990 | N-((3-(2-chlorophenyl)isoxazol-5-yl...) Show SMILES CN(Cc1cc(no1)-c1ccccc1Cl)C(=O)C1CCNCC1 Show InChI InChI=1S/C17H20ClN3O2/c1-21(17(22)12-6-8-19-9-7-12)11-13-10-16(20-23-13)14-4-2-3-5-15(14)18/h2-5,10,12,19H,6-9,11H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Activation of human alpha3beta4 nAChR assessed as potentiation of submaximal response to nicotine induced current				Bioorg Med Chem Lett 18: 5209-12 (2008) Article DOI: 10.1016/j.bmcl.2008.08.080 BindingDB Entry DOI: 10.7270/Q2SX6D26
					More data for this Ligand-Target Pair
Cholinergic, Nicotinic Alpha3Beta2 (Homo sapiens (Human))	BDBM50264882 (CHEMBL497990 | N-((3-(2-chlorophenyl)isoxazol-5-yl...) Show SMILES CN(Cc1cc(no1)-c1ccccc1Cl)C(=O)C1CCNCC1 Show InChI InChI=1S/C17H20ClN3O2/c1-21(17(22)12-6-8-19-9-7-12)11-13-10-16(20-23-13)14-4-2-3-5-15(14)18/h2-5,10,12,19H,6-9,11H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Activation of human alpha3beta2 nAChR assessed as potentiation of submaximal response to nicotine induced current				Bioorg Med Chem Lett 18: 5209-12 (2008) Article DOI: 10.1016/j.bmcl.2008.08.080 BindingDB Entry DOI: 10.7270/Q2SX6D26
					More data for this Ligand-Target Pair