BDBM50265176 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol::CHEMBL497971
SMILES: OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(O)cc2)c1
InChI Key: InChIKey=ODQAIMBPQWETBE-FQBWVUSXSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium/glucose cotransporter 2 (Homo sapiens (Human)) | BDBM50265176 ((2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)ph...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake by fluorescence polarization assay | Bioorg Med Chem Lett 18: 4944-7 (2008) Article DOI: 10.1016/j.bmcl.2008.08.036 BindingDB Entry DOI: 10.7270/Q27944J7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/glucose cotransporter 1 (SGLT1) (Homo sapiens (Human)) | BDBM50265176 ((2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)ph...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human SGLT2 expressed in african green monkey COS7 cells assessed as inhibition of [14C]-methyl-alpha-D-glucopyranoside uptake after 2 ... | Bioorg Med Chem Lett 21: 4465-70 (2011) Article DOI: 10.1016/j.bmcl.2011.06.032 BindingDB Entry DOI: 10.7270/Q29W0FVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium/glucose cotransporter 2 (Homo sapiens (Human)) | BDBM50265176 ((2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)ph...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 970 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human SGLT1 expressed in human 293 cells assessed as inhibition of [14C]-methyl-alpha-D-glucopyranoside uptake after 1.5 hrs by scintil... | Bioorg Med Chem Lett 21: 4465-70 (2011) Article DOI: 10.1016/j.bmcl.2011.06.032 BindingDB Entry DOI: 10.7270/Q29W0FVZ | |||||||||||
More data for this Ligand-Target Pair |