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BDBM50265178 CHEMBL521565::N-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)benzyl)-N-methylbenzamide

SMILES: CN(Cc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1)C(=O)c1ccccc1

InChI Key: InChIKey=YKRBXSNVGLHYGK-SEFGFODJSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50265178   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50265178
PNG
(CHEMBL521565 | N-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-...)
Show SMILES CN(Cc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1)C(=O)c1ccccc1 |r|
Show InChI InChI=1S/C28H30ClNO6/c1-30(28(35)19-5-3-2-4-6-19)15-18-9-7-17(8-10-18)13-21-14-20(11-12-22(21)29)27-26(34)25(33)24(32)23(16-31)36-27/h2-12,14,23-27,31-34H,13,15-16H2,1H3/t23-,24-,25+,26-,27+/m1/s1
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Similars
Article
PubMed
n/an/a 45n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake by fluorescence polarization assay

Bioorg Med Chem Lett 18: 4944-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.036
BindingDB Entry DOI: 10.7270/Q27944J7
More data for this
Ligand-Target Pair