BDBM50265204 (+/-)-2-amino-N-(2-(1-methyl-4-(4-(methylthio)benzamido)piperidin-3-ylamino)-2-oxoethyl)-5-(trifluoromethyl)benzamide::CHEMBL496343

SMILES: CSc1ccc(cc1)C(=O)NC1CCN(C)CC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F

InChI Key: InChIKey=JZTKKQOTCBZVAE-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50265204   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50265204 ((+/-)-2-amino-N-(2-(1-methyl-4-(4-(methylthio)benz...) Show SMILES CSc1ccc(cc1)C(=O)NC1CCN(C)CC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F Show InChI InChI=1S/C24H28F3N5O3S/c1-32-10-9-19(31-22(34)14-3-6-16(36-2)7-4-14)20(13-32)30-21(33)12-29-23(35)17-11-15(24(25,26)27)5-8-18(17)28/h3-8,11,19-20H,9-10,12-13,28H2,1-2H3,(H,29,35)(H,30,33)(H,31,34)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Displacement of radiolabeled MCP1 from CCR2 in human PBMC by millipore filter plate assay				Bioorg Med Chem Lett 18: 5063-5 (2008) Article DOI: 10.1016/j.bmcl.2008.07.123 BindingDB Entry DOI: 10.7270/Q23N236S
					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50265204 ((+/-)-2-amino-N-(2-(1-methyl-4-(4-(methylthio)benz...) Show SMILES CSc1ccc(cc1)C(=O)NC1CCN(C)CC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F Show InChI InChI=1S/C24H28F3N5O3S/c1-32-10-9-19(31-22(34)14-3-6-16(36-2)7-4-14)20(13-32)30-21(33)12-29-23(35)17-11-15(24(25,26)27)5-8-18(17)28/h3-8,11,19-20H,9-10,12-13,28H2,1-2H3,(H,29,35)(H,30,33)(H,31,34)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	38.5	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced chemotaxis				Bioorg Med Chem Lett 18: 5063-5 (2008) Article DOI: 10.1016/j.bmcl.2008.07.123 BindingDB Entry DOI: 10.7270/Q23N236S
					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50265204 ((+/-)-2-amino-N-(2-(1-methyl-4-(4-(methylthio)benz...) Show SMILES CSc1ccc(cc1)C(=O)NC1CCN(C)CC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F Show InChI InChI=1S/C24H28F3N5O3S/c1-32-10-9-19(31-22(34)14-3-6-16(36-2)7-4-14)20(13-32)30-21(33)12-29-23(35)17-11-15(24(25,26)27)5-8-18(17)28/h3-8,11,19-20H,9-10,12-13,28H2,1-2H3,(H,29,35)(H,30,33)(H,31,34)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced calcium flux by fluorescence-imaging plate assay				Bioorg Med Chem Lett 18: 5063-5 (2008) Article DOI: 10.1016/j.bmcl.2008.07.123 BindingDB Entry DOI: 10.7270/Q23N236S
					More data for this Ligand-Target Pair