BDBM50265204 (+/-)-2-amino-N-(2-(1-methyl-4-(4-(methylthio)benzamido)piperidin-3-ylamino)-2-oxoethyl)-5-(trifluoromethyl)benzamide::CHEMBL496343
SMILES: CSc1ccc(cc1)C(=O)NC1CCN(C)CC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F
InChI Key: InChIKey=JZTKKQOTCBZVAE-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50265204 ((+/-)-2-amino-N-(2-(1-methyl-4-(4-(methylthio)benz...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company Curated by ChEMBL | Assay Description Displacement of radiolabeled MCP1 from CCR2 in human PBMC by millipore filter plate assay | Bioorg Med Chem Lett 18: 5063-5 (2008) Article DOI: 10.1016/j.bmcl.2008.07.123 BindingDB Entry DOI: 10.7270/Q23N236S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50265204 ((+/-)-2-amino-N-(2-(1-methyl-4-(4-(methylthio)benz...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 38.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company Curated by ChEMBL | Assay Description Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced chemotaxis | Bioorg Med Chem Lett 18: 5063-5 (2008) Article DOI: 10.1016/j.bmcl.2008.07.123 BindingDB Entry DOI: 10.7270/Q23N236S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM50265204 ((+/-)-2-amino-N-(2-(1-methyl-4-(4-(methylthio)benz...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company Curated by ChEMBL | Assay Description Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced calcium flux by fluorescence-imaging plate assay | Bioorg Med Chem Lett 18: 5063-5 (2008) Article DOI: 10.1016/j.bmcl.2008.07.123 BindingDB Entry DOI: 10.7270/Q23N236S | |||||||||||
More data for this Ligand-Target Pair |