BDBM50265318 6,6-dimethyl-2-(6-(1-(pyridin-3-ylmethyl)-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one::CHEMBL496541

SMILES: CC1(C)Cc2nc(sc2C(=O)N1)N1CCOc2ccc(cc12)-c1cnn(Cc2cccnc2)c1

InChI Key: InChIKey=CUMZRJYMUMFVHW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50265318   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM50265318 (6,6-dimethyl-2-(6-(1-(pyridin-3-ylmethyl)-1H-pyraz...) Show SMILES CC1(C)Cc2nc(sc2C(=O)N1)N1CCOc2ccc(cc12)-c1cnn(Cc2cccnc2)c1 Show InChI InChI=1S/C25H24N6O2S/c1-25(2)11-19-22(23(32)29-25)34-24(28-19)31-8-9-33-21-6-5-17(10-20(21)31)18-13-27-30(15-18)14-16-4-3-7-26-12-16/h3-7,10,12-13,15H,8-9,11,14H2,1-2H3,(H,29,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
UCB Curated by ChEMBL					Assay Description Inhibition of PI3Kgamma (unknown origin)				Bioorg Med Chem Lett 18: 5299-302 (2008) Article DOI: 10.1016/j.bmcl.2008.08.042 BindingDB Entry DOI: 10.7270/Q2WS8T3X
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM50265318 (6,6-dimethyl-2-(6-(1-(pyridin-3-ylmethyl)-1H-pyraz...) Show SMILES CC1(C)Cc2nc(sc2C(=O)N1)N1CCOc2ccc(cc12)-c1cnn(Cc2cccnc2)c1 Show InChI InChI=1S/C25H24N6O2S/c1-25(2)11-19-22(23(32)29-25)34-24(28-19)31-8-9-33-21-6-5-17(10-20(21)31)18-13-27-30(15-18)14-16-4-3-7-26-12-16/h3-7,10,12-13,15H,8-9,11,14H2,1-2H3,(H,29,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
UCB Curated by ChEMBL					Assay Description Inhibition of PI3Kdelta (unknown origin)				Bioorg Med Chem Lett 18: 5299-302 (2008) Article DOI: 10.1016/j.bmcl.2008.08.042 BindingDB Entry DOI: 10.7270/Q2WS8T3X
					More data for this Ligand-Target Pair