BDBM50265737 4-Amino-5-(methylamino)-3-(6-(4-methylpiperazin-1-yl)-1Hbenzo[ d]imidazol-2-yl)quinolin-2(1H)-one::CHEMBL496762

SMILES: CNc1cccc2[nH]c(=O)c(-c3nc4ccc(cc4[nH]3)N3CCN(C)CC3)c(N)c12

InChI Key: InChIKey=JAAZVIPSQFETPP-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50265737   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50265737 (4-Amino-5-(methylamino)-3-(6-(4-methylpiperazin-1-...) Show SMILES CNc1cccc2[nH]c(=O)c(-c3nc4ccc(cc4[nH]3)N3CCN(C)CC3)c(N)c12 Show InChI InChI=1S/C22H25N7O/c1-24-15-4-3-5-16-18(15)20(23)19(22(30)27-16)21-25-14-7-6-13(12-17(14)26-21)29-10-8-28(2)9-11-29/h3-7,12,24H,8-11H2,1-2H3,(H,25,26)(H3,23,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of human recombinant PDGFRbeta				J Med Chem 52: 278-92 (2009) Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50265737 (4-Amino-5-(methylamino)-3-(6-(4-methylpiperazin-1-...) Show SMILES CNc1cccc2[nH]c(=O)c(-c3nc4ccc(cc4[nH]3)N3CCN(C)CC3)c(N)c12 Show InChI InChI=1S/C22H25N7O/c1-24-15-4-3-5-16-18(15)20(23)19(22(30)27-16)21-25-14-7-6-13(12-17(14)26-21)29-10-8-28(2)9-11-29/h3-7,12,24H,8-11H2,1-2H3,(H,25,26)(H3,23,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of human recombinant FGFR1				J Med Chem 52: 278-92 (2009) Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50265737 (4-Amino-5-(methylamino)-3-(6-(4-methylpiperazin-1-...) Show SMILES CNc1cccc2[nH]c(=O)c(-c3nc4ccc(cc4[nH]3)N3CCN(C)CC3)c(N)c12 Show InChI InChI=1S/C22H25N7O/c1-24-15-4-3-5-16-18(15)20(23)19(22(30)27-16)21-25-14-7-6-13(12-17(14)26-21)29-10-8-28(2)9-11-29/h3-7,12,24H,8-11H2,1-2H3,(H,25,26)(H3,23,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for Biomedical Research Curated by ChEMBL					Assay Description Inhibition of human recombinant VEGFR2				J Med Chem 52: 278-92 (2009) Article DOI: 10.1021/jm800790t BindingDB Entry DOI: 10.7270/Q2TD9X7X
					More data for this Ligand-Target Pair