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BDBM50265846 3-(2-(2-methoxy-4-(1-propylpiperidin-4-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)thiophene-2-carboxamide::CHEMBL515846

SMILES: CCCN1CCC(CC1)c1ccc(Nc2nc(Nc3ccsc3C(N)=O)c3cc[nH]c3n2)c(OC)c1

InChI Key: InChIKey=MMNHSQXMGMJMBM-UHFFFAOYSA-N

Data: 2 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50265846   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50265846
PNG
(3-(2-(2-methoxy-4-(1-propylpiperidin-4-yl)phenylam...)
Show SMILES CCCN1CCC(CC1)c1ccc(Nc2nc(Nc3ccsc3C(N)=O)c3cc[nH]c3n2)c(OC)c1
Show InChI InChI=1S/C26H31N7O2S/c1-3-11-33-12-7-16(8-13-33)17-4-5-19(21(15-17)35-2)30-26-31-24-18(6-10-28-24)25(32-26)29-20-9-14-36-22(20)23(27)34/h4-6,9-10,14-16H,3,7-8,11-13H2,1-2H3,(H2,27,34)(H3,28,29,30,31,32)
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.30n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of IGF1R


Bioorg Med Chem Lett 19: 373-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.065
BindingDB Entry DOI: 10.7270/Q2F190PC
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50265846
PNG
(3-(2-(2-methoxy-4-(1-propylpiperidin-4-yl)phenylam...)
Show SMILES CCCN1CCC(CC1)c1ccc(Nc2nc(Nc3ccsc3C(N)=O)c3cc[nH]c3n2)c(OC)c1
Show InChI InChI=1S/C26H31N7O2S/c1-3-11-33-12-7-16(8-13-33)17-4-5-19(21(15-17)35-2)30-26-31-24-18(6-10-28-24)25(32-26)29-20-9-14-36-22(20)23(27)34/h4-6,9-10,14-16H,3,7-8,11-13H2,1-2H3,(H2,27,34)(H3,28,29,30,31,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 52n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of IGF1R phosphorylation by cellular assay


Bioorg Med Chem Lett 19: 373-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.065
BindingDB Entry DOI: 10.7270/Q2F190PC
More data for this
Ligand-Target Pair