BDBM50265873 7-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin-6-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)isoindolin-1-one::CHEMBL517163

SMILES: COc1cc2CCN(C(=O)CN(C)C)c2cc1Nc1nc(Nc2cccc3CNC(=O)c23)c2cc[nH]c2n1

InChI Key: InChIKey=KTQGBACJIGNCAB-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50265873   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50265873 (7-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin...) Show SMILES COc1cc2CCN(C(=O)CN(C)C)c2cc1Nc1nc(Nc2cccc3CNC(=O)c23)c2cc[nH]c2n1 Show InChI InChI=1S/C27H28N8O3/c1-34(2)14-22(36)35-10-8-15-11-21(38-3)19(12-20(15)35)31-27-32-24-17(7-9-28-24)25(33-27)30-18-6-4-5-16-13-29-26(37)23(16)18/h4-7,9,11-12H,8,10,13-14H2,1-3H3,(H,29,37)(H3,28,30,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of IGF1R				Bioorg Med Chem Lett 19: 373-7 (2008) Article DOI: 10.1016/j.bmcl.2008.11.065 BindingDB Entry DOI: 10.7270/Q2F190PC
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50265873 (7-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin...) Show SMILES COc1cc2CCN(C(=O)CN(C)C)c2cc1Nc1nc(Nc2cccc3CNC(=O)c23)c2cc[nH]c2n1 Show InChI InChI=1S/C27H28N8O3/c1-34(2)14-22(36)35-10-8-15-11-21(38-3)19(12-20(15)35)31-27-32-24-17(7-9-28-24)25(33-27)30-18-6-4-5-16-13-29-26(37)23(16)18/h4-7,9,11-12H,8,10,13-14H2,1-3H3,(H,29,37)(H3,28,30,31,32,33)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of AKT				Bioorg Med Chem Lett 19: 373-7 (2008) Article DOI: 10.1016/j.bmcl.2008.11.065 BindingDB Entry DOI: 10.7270/Q2F190PC
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50265873 (7-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin...) Show SMILES COc1cc2CCN(C(=O)CN(C)C)c2cc1Nc1nc(Nc2cccc3CNC(=O)c23)c2cc[nH]c2n1 Show InChI InChI=1S/C27H28N8O3/c1-34(2)14-22(36)35-10-8-15-11-21(38-3)19(12-20(15)35)31-27-32-24-17(7-9-28-24)25(33-27)30-18-6-4-5-16-13-29-26(37)23(16)18/h4-7,9,11-12H,8,10,13-14H2,1-3H3,(H,29,37)(H3,28,30,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of PI3K				Bioorg Med Chem Lett 19: 373-7 (2008) Article DOI: 10.1016/j.bmcl.2008.11.065 BindingDB Entry DOI: 10.7270/Q2F190PC
					More data for this Ligand-Target Pair
Insulin-like growth factor I receptor (Homo sapiens (Human))	BDBM50265873 (7-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin...) Show SMILES COc1cc2CCN(C(=O)CN(C)C)c2cc1Nc1nc(Nc2cccc3CNC(=O)c23)c2cc[nH]c2n1 Show InChI InChI=1S/C27H28N8O3/c1-34(2)14-22(36)35-10-8-15-11-21(38-3)19(12-20(15)35)31-27-32-24-17(7-9-28-24)25(33-27)30-18-6-4-5-16-13-29-26(37)23(16)18/h4-7,9,11-12H,8,10,13-14H2,1-3H3,(H,29,37)(H3,28,30,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of IGF1R phosphorylation by cellular assay				Bioorg Med Chem Lett 19: 373-7 (2008) Article DOI: 10.1016/j.bmcl.2008.11.065 BindingDB Entry DOI: 10.7270/Q2F190PC
					More data for this Ligand-Target Pair