Found 5 hits for monomerid = 50265936 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50265936
(CHEMBL4068705)Show SMILES Cc1cccc(CN2CCc3[nH]c(cc3C2=O)-c2ccnc(NC3CCOCC3)n2)n1 Show InChI InChI=1S/C23H26N6O2/c1-15-3-2-4-17(25-15)14-29-10-6-19-18(22(29)30)13-21(27-19)20-5-9-24-23(28-20)26-16-7-11-31-12-8-16/h2-5,9,13,16,27H,6-8,10-12,14H2,1H3,(H,24,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.470 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of ERK2 (unknown origin) in the presence of 60 uM ATP |
J Med Chem 60: 3438-3450 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00267 BindingDB Entry DOI: 10.7270/Q2FJ2K8J |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50265936
(CHEMBL4068705)Show SMILES Cc1cccc(CN2CCc3[nH]c(cc3C2=O)-c2ccnc(NC3CCOCC3)n2)n1 Show InChI InChI=1S/C23H26N6O2/c1-15-3-2-4-17(25-15)14-29-10-6-19-18(22(29)30)13-21(27-19)20-5-9-24-23(28-20)26-16-7-11-31-12-8-16/h2-5,9,13,16,27H,6-8,10-12,14H2,1H3,(H,24,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of ERK2 (unknown origin) in the presence of 1 mM ATP |
J Med Chem 60: 3438-3450 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00267 BindingDB Entry DOI: 10.7270/Q2FJ2K8J |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50265936
(CHEMBL4068705)Show SMILES Cc1cccc(CN2CCc3[nH]c(cc3C2=O)-c2ccnc(NC3CCOCC3)n2)n1 Show InChI InChI=1S/C23H26N6O2/c1-15-3-2-4-17(25-15)14-29-10-6-19-18(22(29)30)13-21(27-19)20-5-9-24-23(28-20)26-16-7-11-31-12-8-16/h2-5,9,13,16,27H,6-8,10-12,14H2,1H3,(H,24,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated RSK levels |
J Med Chem 60: 3438-3450 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00267 BindingDB Entry DOI: 10.7270/Q2FJ2K8J |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50265936
(CHEMBL4068705)Show SMILES Cc1cccc(CN2CCc3[nH]c(cc3C2=O)-c2ccnc(NC3CCOCC3)n2)n1 Show InChI InChI=1S/C23H26N6O2/c1-15-3-2-4-17(25-15)14-29-10-6-19-18(22(29)30)13-21(27-19)20-5-9-24-23(28-20)26-16-7-11-31-12-8-16/h2-5,9,13,16,27H,6-8,10-12,14H2,1H3,(H,24,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of ERK2 in human A375 cells harboring BRAF V600E mutant assessed as decrease in phosphorylated ERK2 levels |
J Med Chem 60: 3438-3450 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00267 BindingDB Entry DOI: 10.7270/Q2FJ2K8J |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50265936
(CHEMBL4068705)Show SMILES Cc1cccc(CN2CCc3[nH]c(cc3C2=O)-c2ccnc(NC3CCOCC3)n2)n1 Show InChI InChI=1S/C23H26N6O2/c1-15-3-2-4-17(25-15)14-29-10-6-19-18(22(29)30)13-21(27-19)20-5-9-24-23(28-20)26-16-7-11-31-12-8-16/h2-5,9,13,16,27H,6-8,10-12,14H2,1H3,(H,24,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of MEK1 (unknown origin) |
J Med Chem 60: 3438-3450 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00267 BindingDB Entry DOI: 10.7270/Q2FJ2K8J |
More data for this Ligand-Target Pair | |