BDBM50266072 (+/-)-ethyl 2-(N-(1,4-dioxaspiro[4.5]decan-8-yl)-1-naphthamido)-3-(4-chlorophenyl)propanoate::CHEMBL465377

SMILES: CCOC(=O)C(Cc1ccc(Cl)cc1)N(C1CCC2(CC1)OCCO2)C(=O)c1cccc2ccccc12

InChI Key: InChIKey=BBJLFAYVLUMMBT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50266072   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C5a anaphylatoxin chemotactic receptor (C5aR) (Homo sapiens (Human))	BDBM50266072 ((+/-)-ethyl 2-(N-(1,4-dioxaspiro[4.5]decan-8-yl)-1...) Show SMILES CCOC(=O)C(Cc1ccc(Cl)cc1)N(C1CCC2(CC1)OCCO2)C(=O)c1cccc2ccccc12 Show InChI InChI=1S/C30H32ClNO5/c1-2-35-29(34)27(20-21-10-12-23(31)13-11-21)32(24-14-16-30(17-15-24)36-18-19-37-30)28(33)26-9-5-7-22-6-3-4-8-25(22)26/h3-13,24,27H,2,14-20H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Antagonist activity at C5a receptor assessed as inhibition of C5a-induced elastase release in human neutrophils during degranulation preincubated 5 m...				Bioorg Med Chem Lett 18: 5605-8 (2008) Article DOI: 10.1016/j.bmcl.2008.08.101 BindingDB Entry DOI: 10.7270/Q2M61K31
					More data for this Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR) (Homo sapiens (Human))	BDBM50266072 ((+/-)-ethyl 2-(N-(1,4-dioxaspiro[4.5]decan-8-yl)-1...) Show SMILES CCOC(=O)C(Cc1ccc(Cl)cc1)N(C1CCC2(CC1)OCCO2)C(=O)c1cccc2ccccc12 Show InChI InChI=1S/C30H32ClNO5/c1-2-35-29(34)27(20-21-10-12-23(31)13-11-21)32(24-14-16-30(17-15-24)36-18-19-37-30)28(33)26-9-5-7-22-6-3-4-8-25(22)26/h3-13,24,27H,2,14-20H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Displacement of [125I]C5a from C5a receptor in cAMP differentiated human U937 cells by filtration assay				Bioorg Med Chem Lett 18: 5605-8 (2008) Article DOI: 10.1016/j.bmcl.2008.08.101 BindingDB Entry DOI: 10.7270/Q2M61K31
					More data for this Ligand-Target Pair