BDBM50266091 1-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea::1-[3-methyl-4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)phenyl]-3-[3-(trifluoromethyl)phenyl]urea::CHEMBL468612

SMILES: CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1C

InChI Key: InChIKey=INFGJUQNPPGDNS-UHFFFAOYSA-N

Data: 2 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50266091   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50266091 (1-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1C Show InChI InChI=1S/C25H21F3N6O2/c1-15-13-18(33-24(35)32-17-6-3-5-16(14-17)25(26,27)28)8-9-21(15)36-22-19(7-4-11-30-22)20-10-12-31-23(29-2)34-20/h3-14H,1-2H3,(H,29,31,34)(H2,32,33,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 19: 424-7 (2008) Article DOI: 10.1016/j.bmcl.2008.11.056 BindingDB Entry DOI: 10.7270/Q29P31HK
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50266091 (1-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1C Show InChI InChI=1S/C25H21F3N6O2/c1-15-13-18(33-24(35)32-17-6-3-5-16(14-17)25(26,27)28)8-9-21(15)36-22-19(7-4-11-30-22)20-10-12-31-23(29-2)34-20/h3-14H,1-2H3,(H,29,31,34)(H2,32,33,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2 (unknown origin)				Bioorg Med Chem Lett 19: 424-7 (2008) Article DOI: 10.1016/j.bmcl.2008.11.056 BindingDB Entry DOI: 10.7270/Q29P31HK
					More data for this Ligand-Target Pair