BDBM50266118 CHEMBL516817::N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-1H-benzo[d]imidazol-2-amine

SMILES: CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nc3ccccc3[nH]2)cc1C

InChI Key: InChIKey=FJEANKNQOKTYTP-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50266118   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50266118 (CHEMBL516817 | N-(3-methyl-4-(3-(2-(methylamino)py...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nc3ccccc3[nH]2)cc1C Show InChI InChI=1S/C24H21N7O/c1-15-14-16(28-24-30-19-7-3-4-8-20(19)31-24)9-10-21(15)32-22-17(6-5-12-26-22)18-11-13-27-23(25-2)29-18/h3-14H,1-2H3,(H,25,27,29)(H2,28,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2 (unknown origin)				Bioorg Med Chem Lett 19: 424-7 (2008) Article DOI: 10.1016/j.bmcl.2008.11.056 BindingDB Entry DOI: 10.7270/Q29P31HK
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50266118 (CHEMBL516817 | N-(3-methyl-4-(3-(2-(methylamino)py...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nc3ccccc3[nH]2)cc1C Show InChI InChI=1S/C24H21N7O/c1-15-14-16(28-24-30-19-7-3-4-8-20(19)31-24)9-10-21(15)32-22-17(6-5-12-26-22)18-11-13-27-23(25-2)29-18/h3-14H,1-2H3,(H,25,27,29)(H2,28,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Tie2				Bioorg Med Chem Lett 19: 424-7 (2008) Article DOI: 10.1016/j.bmcl.2008.11.056 BindingDB Entry DOI: 10.7270/Q29P31HK
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50266118 (CHEMBL516817 | N-(3-methyl-4-(3-(2-(methylamino)py...) Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nc3ccccc3[nH]2)cc1C Show InChI InChI=1S/C24H21N7O/c1-15-14-16(28-24-30-19-7-3-4-8-20(19)31-24)9-10-21(15)32-22-17(6-5-12-26-22)18-11-13-27-23(25-2)29-18/h3-14H,1-2H3,(H,25,27,29)(H2,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 19: 424-7 (2008) Article DOI: 10.1016/j.bmcl.2008.11.056 BindingDB Entry DOI: 10.7270/Q29P31HK
					More data for this Ligand-Target Pair