BDBM50266236 (S)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-(2-oxotetrahydrofuran-3-yl)acetamide::CHEMBL511677
SMILES: Fc1ccc(CC(=O)N[C@H]2CCOC2=O)cc1C(F)(F)F
InChI Key: InChIKey=UXKGQLOVTJTXOI-JTQLQIEISA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Transcriptional activator protein luxR (Vibrio fischeri (strain ATCC 700601 / ES114)) | BDBM50266236 ((S)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-(2-ox...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison Curated by ChEMBL | Assay Description Antagonist activity at Vibrio fischeri ES114 LuxR receptor assessed as inhibition of OHHL-induced response by luciferase reporter gene assay | Bioorg Med Chem Lett 18: 5978-81 (2008) Article DOI: 10.1016/j.bmcl.2008.07.089 BindingDB Entry DOI: 10.7270/Q2Q81CXX | |||||||||||
More data for this Ligand-Target Pair |