BDBM50266877 CHEMBL4098976

SMILES: OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(F)c(F)c1)-c1ccc(F)cc1

InChI Key: InChIKey=AWQSVYZFVWIJTA-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50266877   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM50266877 (CHEMBL4098976) Show SMILES OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(F)c(F)c1)-c1ccc(F)cc1 |(17.08,-16.49,;17.85,-15.17,;17.08,-13.82,;19.39,-15.17,;20.29,-16.42,;21.76,-15.92,;23.1,-16.69,;24.43,-15.92,;25.76,-16.69,;24.42,-14.37,;23.09,-13.61,;21.76,-14.39,;20.29,-13.91,;19.81,-12.44,;20.72,-11.21,;19.81,-9.96,;18.35,-10.43,;18.35,-11.98,;17.1,-12.89,;15.69,-12.26,;15.53,-10.73,;14.12,-10.11,;12.88,-11.01,;11.47,-10.39,;13.04,-12.55,;11.8,-13.45,;14.45,-13.17,;22.26,-11.21,;23.02,-12.55,;24.56,-12.55,;25.34,-11.22,;26.88,-11.22,;24.57,-9.88,;23.03,-9.88,)| Show InChI InChI=1S/C25H15ClF3N3O2/c26-15-4-7-17-20(10-15)31-23(25(33)34)21(17)24-22(14-2-5-16(27)6-3-14)30-12-32(24)11-13-1-8-18(28)19(29)9-13/h1-10,12,31H,11H2,(H,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Binding affinity to human N-terminal MDM2 (1 to 118 residues) expressed in Escherichia coli BL21 (DE3) after 15 mins in presence of 5-FAM-LTFEHYWAQLT...				J Med Chem 60: 4234-4244 (2017) Article DOI: 10.1021/acs.jmedchem.7b00104 BindingDB Entry DOI: 10.7270/Q2BK1FT3
					More data for this Ligand-Target Pair
p53-Binding Protein HDMX (Homo sapiens (Human))	BDBM50266877 (CHEMBL4098976) Show SMILES OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(F)c(F)c1)-c1ccc(F)cc1 |(17.08,-16.49,;17.85,-15.17,;17.08,-13.82,;19.39,-15.17,;20.29,-16.42,;21.76,-15.92,;23.1,-16.69,;24.43,-15.92,;25.76,-16.69,;24.42,-14.37,;23.09,-13.61,;21.76,-14.39,;20.29,-13.91,;19.81,-12.44,;20.72,-11.21,;19.81,-9.96,;18.35,-10.43,;18.35,-11.98,;17.1,-12.89,;15.69,-12.26,;15.53,-10.73,;14.12,-10.11,;12.88,-11.01,;11.47,-10.39,;13.04,-12.55,;11.8,-13.45,;14.45,-13.17,;22.26,-11.21,;23.02,-12.55,;24.56,-12.55,;25.34,-11.22,;26.88,-11.22,;24.57,-9.88,;23.03,-9.88,)| Show InChI InChI=1S/C25H15ClF3N3O2/c26-15-4-7-17-20(10-15)31-23(25(33)34)21(17)24-22(14-2-5-16(27)6-3-14)30-12-32(24)11-13-1-8-18(28)19(29)9-13/h1-10,12,31H,11H2,(H,33,34)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4.91E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Binding affinity to human N-terminal MDMx (1 to 134 residues) expressed in Escherichia coli BL21 (DE3) after 15 mins in presence of 5-FAM-LTFEHYWAQLT...				J Med Chem 60: 4234-4244 (2017) Article DOI: 10.1021/acs.jmedchem.7b00104 BindingDB Entry DOI: 10.7270/Q2BK1FT3
					More data for this Ligand-Target Pair