BDBM50266883 CHEMBL4067165

SMILES: OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(OCc2ccccc2Br)cc1)-c1ccc(F)cc1

InChI Key: InChIKey=UUIUQZOIVINEJE-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50266883   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM50266883 (CHEMBL4067165) Show SMILES OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(OCc2ccccc2Br)cc1)-c1ccc(F)cc1 |(20.01,-19.68,;21.19,-18.7,;20.93,-17.18,;22.64,-19.23,;23.05,-20.72,;24.6,-20.78,;25.59,-21.97,;27.11,-21.72,;28.09,-22.91,;27.65,-20.27,;26.66,-19.08,;25.14,-19.34,;23.92,-18.37,;23.99,-16.83,;25.26,-15.97,;24.87,-14.5,;23.32,-14.44,;22.76,-15.82,;21.27,-16.2,;20.14,-15.16,;20.48,-13.63,;19.38,-12.59,;17.9,-13.06,;16.76,-12.01,;15.28,-12.47,;14.94,-13.98,;16.08,-15.01,;15.74,-16.51,;14.27,-16.97,;13.13,-15.92,;13.48,-14.42,;12.36,-13.37,;17.57,-14.55,;18.7,-15.59,;26.71,-16.49,;26.97,-18.01,;28.42,-18.53,;29.6,-17.54,;31.03,-18.06,;29.32,-16.02,;27.87,-15.5,)| Show InChI InChI=1S/C32H22BrClFN3O3/c33-26-4-2-1-3-21(26)17-41-24-12-5-19(6-13-24)16-38-18-36-29(20-7-10-23(35)11-8-20)31(38)28-25-14-9-22(34)15-27(25)37-30(28)32(39)40/h1-15,18,37H,16-17H2,(H,39,40)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	157	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Binding affinity to human N-terminal MDM2 (1 to 118 residues) expressed in Escherichia coli BL21 (DE3) after 15 mins in presence of 5-FAM-LTFEHYWAQLT...				J Med Chem 60: 4234-4244 (2017) Article DOI: 10.1021/acs.jmedchem.7b00104 BindingDB Entry DOI: 10.7270/Q2BK1FT3
					More data for this Ligand-Target Pair
p53-Binding Protein HDMX (Homo sapiens (Human))	BDBM50266883 (CHEMBL4067165) Show SMILES OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(OCc2ccccc2Br)cc1)-c1ccc(F)cc1 |(20.01,-19.68,;21.19,-18.7,;20.93,-17.18,;22.64,-19.23,;23.05,-20.72,;24.6,-20.78,;25.59,-21.97,;27.11,-21.72,;28.09,-22.91,;27.65,-20.27,;26.66,-19.08,;25.14,-19.34,;23.92,-18.37,;23.99,-16.83,;25.26,-15.97,;24.87,-14.5,;23.32,-14.44,;22.76,-15.82,;21.27,-16.2,;20.14,-15.16,;20.48,-13.63,;19.38,-12.59,;17.9,-13.06,;16.76,-12.01,;15.28,-12.47,;14.94,-13.98,;16.08,-15.01,;15.74,-16.51,;14.27,-16.97,;13.13,-15.92,;13.48,-14.42,;12.36,-13.37,;17.57,-14.55,;18.7,-15.59,;26.71,-16.49,;26.97,-18.01,;28.42,-18.53,;29.6,-17.54,;31.03,-18.06,;29.32,-16.02,;27.87,-15.5,)| Show InChI InChI=1S/C32H22BrClFN3O3/c33-26-4-2-1-3-21(26)17-41-24-12-5-19(6-13-24)16-38-18-36-29(20-7-10-23(35)11-8-20)31(38)28-25-14-9-22(34)15-27(25)37-30(28)32(39)40/h1-15,18,37H,16-17H2,(H,39,40)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4.17E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Curated by ChEMBL					Assay Description Binding affinity to human N-terminal MDMx (1 to 134 residues) expressed in Escherichia coli BL21 (DE3) after 15 mins in presence of 5-FAM-LTFEHYWAQLT...				J Med Chem 60: 4234-4244 (2017) Article DOI: 10.1021/acs.jmedchem.7b00104 BindingDB Entry DOI: 10.7270/Q2BK1FT3
					More data for this Ligand-Target Pair