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SMILES: CO[C@]1(C)C[C@@H](N(C1)C(=O)Nc1ccc(Cl)cc1)C(=O)Nc1ccc(cc1F)-n1ccccc1=O

InChI Key: InChIKey=JDCYSXQYWOYDRV-PXDATVDWSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50266891   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Coagulation factor X


(Homo sapiens (Human))		BDBM50266891
PNG
((2R,4R)-N1-(4-Chlorophenyl)-N2-(2-fluoro-4-(2-oxop...)
Show SMILES CO[C@]1(C)C[C@@H](N(C1)C(=O)Nc1ccc(Cl)cc1)C(=O)Nc1ccc(cc1F)-n1ccccc1=O |r|
Show InChI InChI=1S/C25H24ClFN4O4/c1-25(35-2)14-21(31(15-25)24(34)28-17-8-6-16(26)7-9-17)23(33)29-20-11-10-18(13-19(20)27)30-12-4-3-5-22(30)32/h3-13,21H,14-15H2,1-2H3,(H,28,34)(H,29,33)/t21-,25-/m1/s1
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Article
PubMed
n/an/a 0.310n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human Factor-10a

Bioorg Med Chem 17: 2501-11 (2009)


Article DOI: 10.1016/j.bmc.2009.01.063
BindingDB Entry DOI: 10.7270/Q2RX9BXD
More data for this
Ligand-Target Pair