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SMILES: OC(C1CC2CC[NH+]1CC2)(c1ccccc1)c1ccccc1

InChI Key: InChIKey=JNZMANQLHCNXTA-UHFFFAOYSA-O

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50267389   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50267389
PNG
(2-(hydroxydiphenylmethyl)-1-azoniabicyclo[2.2.2]oc...)
Show SMILES OC(C1CC2CC[NH+]1CC2)(c1ccccc1)c1ccccc1 |(-4.05,-3.64,;-4.83,-2.31,;-6.17,-3.08,;-6.17,-4.63,;-7.51,-5.4,;-8.84,-4.63,;-8.84,-3.08,;-7.51,-2.3,;-8.14,-3.48,;-6.86,-4.11,;-3.51,-1.53,;-2.18,-2.29,;-.85,-1.51,;-.87,.02,;-2.22,.78,;-3.53,-.01,;-5.6,-.98,;-4.83,.35,;-5.6,1.69,;-7.14,1.69,;-7.91,.35,;-7.14,-.98,)|
Show InChI InChI=1S/C20H23NO/c22-20(17-7-3-1-4-8-17,18-9-5-2-6-10-18)19-15-16-11-13-21(19)14-12-16/h1-10,16,19,22H,11-15H2/p+1
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Article
PubMed
n/an/a 6.60E+6n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilizatio...

J Med Chem 52: 2493-505 (2009)


Article DOI: 10.1021/jm801601v
BindingDB Entry DOI: 10.7270/Q2H131X8
More data for this
Ligand-Target Pair