BDBM50268953 (1S,2S)-N-hydroxy-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide::CHEMBL496212

SMILES: ONC(=O)[C@H]1CCCC[C@@H]1C(=O)N1CCN(CC1)c1ccccc1

InChI Key: InChIKey=UMKOSVICWGLVQX-HOTGVXAUSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50268953   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50268953 ((1S,2S)-N-hydroxy-2-(4-phenylpiperazine-1-carbonyl...) Show SMILES ONC(=O)[C@H]1CCCC[C@@H]1C(=O)N1CCN(CC1)c1ccccc1 |r| Show InChI InChI=1S/C18H25N3O3/c22-17(19-24)15-8-4-5-9-16(15)18(23)21-12-10-20(11-13-21)14-6-2-1-3-7-14/h1-3,6-7,15-16,24H,4-5,8-13H2,(H,19,22)/t15-,16-/m0/s1	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISA				Bioorg Med Chem Lett 19: 3525-30 (2009) Article DOI: 10.1016/j.bmcl.2009.04.143 BindingDB Entry DOI: 10.7270/Q2ST7PRT
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50268953 ((1S,2S)-N-hydroxy-2-(4-phenylpiperazine-1-carbonyl...) Show SMILES ONC(=O)[C@H]1CCCC[C@@H]1C(=O)N1CCN(CC1)c1ccccc1 |r| Show InChI InChI=1S/C18H25N3O3/c22-17(19-24)15-8-4-5-9-16(15)18(23)21-12-10-20(11-13-21)14-6-2-1-3-7-14/h1-3,6-7,15-16,24H,4-5,8-13H2,(H,19,22)/t15-,16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibition of human MMP2				Bioorg Med Chem Lett 19: 3525-30 (2009) Article DOI: 10.1016/j.bmcl.2009.04.143 BindingDB Entry DOI: 10.7270/Q2ST7PRT
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50268953 ((1S,2S)-N-hydroxy-2-(4-phenylpiperazine-1-carbonyl...) Show SMILES ONC(=O)[C@H]1CCCC[C@@H]1C(=O)N1CCN(CC1)c1ccccc1 |r| Show InChI InChI=1S/C18H25N3O3/c22-17(19-24)15-8-4-5-9-16(15)18(23)21-12-10-20(11-13-21)14-6-2-1-3-7-14/h1-3,6-7,15-16,24H,4-5,8-13H2,(H,19,22)/t15-,16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibition of human MMP1				Bioorg Med Chem Lett 19: 3525-30 (2009) Article DOI: 10.1016/j.bmcl.2009.04.143 BindingDB Entry DOI: 10.7270/Q2ST7PRT
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) (Homo sapiens (Human))	BDBM50268953 ((1S,2S)-N-hydroxy-2-(4-phenylpiperazine-1-carbonyl...) Show SMILES ONC(=O)[C@H]1CCCC[C@@H]1C(=O)N1CCN(CC1)c1ccccc1 |r| Show InChI InChI=1S/C18H25N3O3/c22-17(19-24)15-8-4-5-9-16(15)18(23)21-12-10-20(11-13-21)14-6-2-1-3-7-14/h1-3,6-7,15-16,24H,4-5,8-13H2,(H,19,22)/t15-,16-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation Curated by ChEMBL					Assay Description Inhibition of human recombinant ADAM10				Bioorg Med Chem Lett 19: 3525-30 (2009) Article DOI: 10.1016/j.bmcl.2009.04.143 BindingDB Entry DOI: 10.7270/Q2ST7PRT
					More data for this Ligand-Target Pair