Found 6 hits for monomerid = 50269001 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50269001
((1S,2S,5RS)-N-hydroxy-5-(2-(4-methylpiperazin-1-yl...)Show SMILES CN1CCN(CC1)C(=O)CC1CC[C@@H]([C@H](C1)C(=O)NO)C(=O)N1CCN(CC1)c1ccccc1 |r| Show InChI InChI=1S/C25H37N5O4/c1-27-9-11-29(12-10-27)23(31)18-19-7-8-21(22(17-19)24(32)26-34)25(33)30-15-13-28(14-16-30)20-5-3-2-4-6-20/h2-6,19,21-22,34H,7-18H2,1H3,(H,26,32)/t19?,21-,22-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of human MMP9 |
Bioorg Med Chem Lett 19: 3525-30 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.143 BindingDB Entry DOI: 10.7270/Q2ST7PRT |
More data for this Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM50269001
((1S,2S,5RS)-N-hydroxy-5-(2-(4-methylpiperazin-1-yl...)Show SMILES CN1CCN(CC1)C(=O)CC1CC[C@@H]([C@H](C1)C(=O)NO)C(=O)N1CCN(CC1)c1ccccc1 |r| Show InChI InChI=1S/C25H37N5O4/c1-27-9-11-29(12-10-27)23(31)18-19-7-8-21(22(17-19)24(32)26-34)25(33)30-15-13-28(14-16-30)20-5-3-2-4-6-20/h2-6,19,21-22,34H,7-18H2,1H3,(H,26,32)/t19?,21-,22-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of human MMP3 |
Bioorg Med Chem Lett 19: 3525-30 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.143 BindingDB Entry DOI: 10.7270/Q2ST7PRT |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50269001
((1S,2S,5RS)-N-hydroxy-5-(2-(4-methylpiperazin-1-yl...)Show SMILES CN1CCN(CC1)C(=O)CC1CC[C@@H]([C@H](C1)C(=O)NO)C(=O)N1CCN(CC1)c1ccccc1 |r| Show InChI InChI=1S/C25H37N5O4/c1-27-9-11-29(12-10-27)23(31)18-19-7-8-21(22(17-19)24(32)26-34)25(33)30-15-13-28(14-16-30)20-5-3-2-4-6-20/h2-6,19,21-22,34H,7-18H2,1H3,(H,26,32)/t19?,21-,22-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of human MMP2 |
Bioorg Med Chem Lett 19: 3525-30 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.143 BindingDB Entry DOI: 10.7270/Q2ST7PRT |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)
(Homo sapiens (Human)) | BDBM50269001
((1S,2S,5RS)-N-hydroxy-5-(2-(4-methylpiperazin-1-yl...)Show SMILES CN1CCN(CC1)C(=O)CC1CC[C@@H]([C@H](C1)C(=O)NO)C(=O)N1CCN(CC1)c1ccccc1 |r| Show InChI InChI=1S/C25H37N5O4/c1-27-9-11-29(12-10-27)23(31)18-19-7-8-21(22(17-19)24(32)26-34)25(33)30-15-13-28(14-16-30)20-5-3-2-4-6-20/h2-6,19,21-22,34H,7-18H2,1H3,(H,26,32)/t19?,21-,22-/m0/s1 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of human recombinant ADAM10 |
Bioorg Med Chem Lett 19: 3525-30 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.143 BindingDB Entry DOI: 10.7270/Q2ST7PRT |
More data for this Ligand-Target Pair | |
Interstitial collagenase
(Homo sapiens (Human)) | BDBM50269001
((1S,2S,5RS)-N-hydroxy-5-(2-(4-methylpiperazin-1-yl...)Show SMILES CN1CCN(CC1)C(=O)CC1CC[C@@H]([C@H](C1)C(=O)NO)C(=O)N1CCN(CC1)c1ccccc1 |r| Show InChI InChI=1S/C25H37N5O4/c1-27-9-11-29(12-10-27)23(31)18-19-7-8-21(22(17-19)24(32)26-34)25(33)30-15-13-28(14-16-30)20-5-3-2-4-6-20/h2-6,19,21-22,34H,7-18H2,1H3,(H,26,32)/t19?,21-,22-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of human MMP1 |
Bioorg Med Chem Lett 19: 3525-30 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.143 BindingDB Entry DOI: 10.7270/Q2ST7PRT |
More data for this Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM50269001
((1S,2S,5RS)-N-hydroxy-5-(2-(4-methylpiperazin-1-yl...)Show SMILES CN1CCN(CC1)C(=O)CC1CC[C@@H]([C@H](C1)C(=O)NO)C(=O)N1CCN(CC1)c1ccccc1 |r| Show InChI InChI=1S/C25H37N5O4/c1-27-9-11-29(12-10-27)23(31)18-19-7-8-21(22(17-19)24(32)26-34)25(33)30-15-13-28(14-16-30)20-5-3-2-4-6-20/h2-6,19,21-22,34H,7-18H2,1H3,(H,26,32)/t19?,21-,22-/m0/s1 | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISA |
Bioorg Med Chem Lett 19: 3525-30 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.143 BindingDB Entry DOI: 10.7270/Q2ST7PRT |
More data for this Ligand-Target Pair | |