Found 6 hits for monomerid = 50269059 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50269059
((1S,2S,5S)-N-hydroxy-2-(4-(3-isopropylphenyl)piper...)Show SMILES CC(C)c1cccc(c1)C1CCN(CC1)C(=O)[C@H]1CC[C@H](CC(=O)N2CCCCC2)C[C@@H]1C(=O)NO |r| Show InChI InChI=1S/C29H43N3O4/c1-20(2)23-7-6-8-24(19-23)22-11-15-32(16-12-22)29(35)25-10-9-21(17-26(25)28(34)30-36)18-27(33)31-13-4-3-5-14-31/h6-8,19-22,25-26,36H,3-5,9-18H2,1-2H3,(H,30,34)/t21-,25-,26-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of human MMP9 |
Bioorg Med Chem Lett 19: 3525-30 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.143 BindingDB Entry DOI: 10.7270/Q2ST7PRT |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50269059
((1S,2S,5S)-N-hydroxy-2-(4-(3-isopropylphenyl)piper...)Show SMILES CC(C)c1cccc(c1)C1CCN(CC1)C(=O)[C@H]1CC[C@H](CC(=O)N2CCCCC2)C[C@@H]1C(=O)NO |r| Show InChI InChI=1S/C29H43N3O4/c1-20(2)23-7-6-8-24(19-23)22-11-15-32(16-12-22)29(35)25-10-9-21(17-26(25)28(34)30-36)18-27(33)31-13-4-3-5-14-31/h6-8,19-22,25-26,36H,3-5,9-18H2,1-2H3,(H,30,34)/t21-,25-,26-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of human MMP2 |
Bioorg Med Chem Lett 19: 3525-30 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.143 BindingDB Entry DOI: 10.7270/Q2ST7PRT |
More data for this Ligand-Target Pair | |
Interstitial collagenase
(Homo sapiens (Human)) | BDBM50269059
((1S,2S,5S)-N-hydroxy-2-(4-(3-isopropylphenyl)piper...)Show SMILES CC(C)c1cccc(c1)C1CCN(CC1)C(=O)[C@H]1CC[C@H](CC(=O)N2CCCCC2)C[C@@H]1C(=O)NO |r| Show InChI InChI=1S/C29H43N3O4/c1-20(2)23-7-6-8-24(19-23)22-11-15-32(16-12-22)29(35)25-10-9-21(17-26(25)28(34)30-36)18-27(33)31-13-4-3-5-14-31/h6-8,19-22,25-26,36H,3-5,9-18H2,1-2H3,(H,30,34)/t21-,25-,26-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of human MMP1 |
Bioorg Med Chem Lett 19: 3525-30 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.143 BindingDB Entry DOI: 10.7270/Q2ST7PRT |
More data for this Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM50269059
((1S,2S,5S)-N-hydroxy-2-(4-(3-isopropylphenyl)piper...)Show SMILES CC(C)c1cccc(c1)C1CCN(CC1)C(=O)[C@H]1CC[C@H](CC(=O)N2CCCCC2)C[C@@H]1C(=O)NO |r| Show InChI InChI=1S/C29H43N3O4/c1-20(2)23-7-6-8-24(19-23)22-11-15-32(16-12-22)29(35)25-10-9-21(17-26(25)28(34)30-36)18-27(33)31-13-4-3-5-14-31/h6-8,19-22,25-26,36H,3-5,9-18H2,1-2H3,(H,30,34)/t21-,25-,26-/m0/s1 | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISA |
Bioorg Med Chem Lett 19: 3525-30 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.143 BindingDB Entry DOI: 10.7270/Q2ST7PRT |
More data for this Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 10
(Homo sapiens (Human)) | BDBM50269059
((1S,2S,5S)-N-hydroxy-2-(4-(3-isopropylphenyl)piper...)Show SMILES CC(C)c1cccc(c1)C1CCN(CC1)C(=O)[C@H]1CC[C@H](CC(=O)N2CCCCC2)C[C@@H]1C(=O)NO |r| Show InChI InChI=1S/C29H43N3O4/c1-20(2)23-7-6-8-24(19-23)22-11-15-32(16-12-22)29(35)25-10-9-21(17-26(25)28(34)30-36)18-27(33)31-13-4-3-5-14-31/h6-8,19-22,25-26,36H,3-5,9-18H2,1-2H3,(H,30,34)/t21-,25-,26-/m0/s1 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of human recombinant ADAM10 |
Bioorg Med Chem Lett 19: 3525-30 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.143 BindingDB Entry DOI: 10.7270/Q2ST7PRT |
More data for this Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM50269059
((1S,2S,5S)-N-hydroxy-2-(4-(3-isopropylphenyl)piper...)Show SMILES CC(C)c1cccc(c1)C1CCN(CC1)C(=O)[C@H]1CC[C@H](CC(=O)N2CCCCC2)C[C@@H]1C(=O)NO |r| Show InChI InChI=1S/C29H43N3O4/c1-20(2)23-7-6-8-24(19-23)22-11-15-32(16-12-22)29(35)25-10-9-21(17-26(25)28(34)30-36)18-27(33)31-13-4-3-5-14-31/h6-8,19-22,25-26,36H,3-5,9-18H2,1-2H3,(H,30,34)/t21-,25-,26-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation
Curated by ChEMBL
| Assay Description Inhibition of human MMP3 |
Bioorg Med Chem Lett 19: 3525-30 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.143 BindingDB Entry DOI: 10.7270/Q2ST7PRT |
More data for this Ligand-Target Pair | |