BDBM50269901 CHEMBL525748::TPRARRRKKRI

SMILES: [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@@H](-[#7])-[#6@@H](-[#6])-[#8])-[#6](-[#7])=O

InChI Key: InChIKey=ALKYWGCWYLWWQX-WEOSOBNISA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50269901   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA (Homo sapiens (Human))	BDBM50269901 (CHEMBL525748 | TPRARRRKKRI) Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@@H](-[#7])-[#6@@H](-[#6])-[#8])-[#6](-[#7])=O |r| Show InChI InChI=1S/C60H117N29O12/c1-5-32(2)44(45(64)91)88-53(99)41(22-14-30-79-60(73)74)86-49(95)36(17-7-9-25-62)82-48(94)35(16-6-8-24-61)83-51(97)39(20-12-28-77-58(69)70)85-52(98)40(21-13-29-78-59(71)72)84-50(96)38(19-11-27-76-57(67)68)81-46(92)33(3)80-47(93)37(18-10-26-75-56(65)66)87-54(100)42-23-15-31-89(42)55(101)43(63)34(4)90/h32-44,90H,5-31,61-63H2,1-4H3,(H2,64,91)(H,80,93)(H,81,92)(H,82,94)(H,83,97)(H,84,96)(H,85,98)(H,86,95)(H,87,100)(H,88,99)(H4,65,66,75)(H4,67,68,76)(H4,69,70,77)(H4,71,72,78)(H4,73,74,79)/t32-,33-,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Medical Research Curated by ChEMBL					Assay Description Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage				J Biol Chem 282: 20847-53 (2007) Article DOI: 10.1074/jbc.M703847200 BindingDB Entry DOI: 10.7270/Q2057FPB
					More data for this Ligand-Target Pair
Subtilisin/kexin type 7 (Homo sapiens (Human))	BDBM50269901 (CHEMBL525748 | TPRARRRKKRI) Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@@H](-[#7])-[#6@@H](-[#6])-[#8])-[#6](-[#7])=O |r| Show InChI InChI=1S/C60H117N29O12/c1-5-32(2)44(45(64)91)88-53(99)41(22-14-30-79-60(73)74)86-49(95)36(17-7-9-25-62)82-48(94)35(16-6-8-24-61)83-51(97)39(20-12-28-77-58(69)70)85-52(98)40(21-13-29-78-59(71)72)84-50(96)38(19-11-27-76-57(67)68)81-46(92)33(3)80-47(93)37(18-10-26-75-56(65)66)87-54(100)42-23-15-31-89(42)55(101)43(63)34(4)90/h32-44,90H,5-31,61-63H2,1-4H3,(H2,64,91)(H,80,93)(H,81,92)(H,82,94)(H,83,97)(H,84,96)(H,85,98)(H,86,95)(H,87,100)(H,88,99)(H4,65,66,75)(H4,67,68,76)(H4,69,70,77)(H4,71,72,78)(H4,73,74,79)/t32-,33-,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	135	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Medical Research Curated by ChEMBL					Assay Description Inhibition of human recombinant PC7 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage				J Biol Chem 282: 20847-53 (2007) Article DOI: 10.1074/jbc.M703847200 BindingDB Entry DOI: 10.7270/Q2057FPB
					More data for this Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 6 (Rattus norvegicus)	BDBM50269901 (CHEMBL525748 | TPRARRRKKRI) Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@@H](-[#7])-[#6@@H](-[#6])-[#8])-[#6](-[#7])=O |r| Show InChI InChI=1S/C60H117N29O12/c1-5-32(2)44(45(64)91)88-53(99)41(22-14-30-79-60(73)74)86-49(95)36(17-7-9-25-62)82-48(94)35(16-6-8-24-61)83-51(97)39(20-12-28-77-58(69)70)85-52(98)40(21-13-29-78-59(71)72)84-50(96)38(19-11-27-76-57(67)68)81-46(92)33(3)80-47(93)37(18-10-26-75-56(65)66)87-54(100)42-23-15-31-89(42)55(101)43(63)34(4)90/h32-44,90H,5-31,61-63H2,1-4H3,(H2,64,91)(H,80,93)(H,81,92)(H,82,94)(H,83,97)(H,84,96)(H,85,98)(H,86,95)(H,87,100)(H,88,99)(H4,65,66,75)(H4,67,68,76)(H4,69,70,77)(H4,71,72,78)(H4,73,74,79)/t32-,33-,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	267	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Medical Research Curated by ChEMBL					Assay Description Inhibition of rat PACE4 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage				J Biol Chem 282: 20847-53 (2007) Article DOI: 10.1074/jbc.M703847200 BindingDB Entry DOI: 10.7270/Q2057FPB
					More data for this Ligand-Target Pair
Subtilisin/kexin type 5 (Homo sapiens (Human))	BDBM50269901 (CHEMBL525748 | TPRARRRKKRI) Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@@H](-[#7])-[#6@@H](-[#6])-[#8])-[#6](-[#7])=O |r| Show InChI InChI=1S/C60H117N29O12/c1-5-32(2)44(45(64)91)88-53(99)41(22-14-30-79-60(73)74)86-49(95)36(17-7-9-25-62)82-48(94)35(16-6-8-24-61)83-51(97)39(20-12-28-77-58(69)70)85-52(98)40(21-13-29-78-59(71)72)84-50(96)38(19-11-27-76-57(67)68)81-46(92)33(3)80-47(93)37(18-10-26-75-56(65)66)87-54(100)42-23-15-31-89(42)55(101)43(63)34(4)90/h32-44,90H,5-31,61-63H2,1-4H3,(H2,64,91)(H,80,93)(H,81,92)(H,82,94)(H,83,97)(H,84,96)(H,85,98)(H,86,95)(H,87,100)(H,88,99)(H4,65,66,75)(H4,67,68,76)(H4,69,70,77)(H4,71,72,78)(H4,73,74,79)/t32-,33-,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	492	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Medical Research Curated by ChEMBL					Assay Description Inhibition of human recombinant PC5/6 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage				J Biol Chem 282: 20847-53 (2007) Article DOI: 10.1074/jbc.M703847200 BindingDB Entry DOI: 10.7270/Q2057FPB
					More data for this Ligand-Target Pair
Subtilisin/kexin type 4 (Homo sapiens (Human))	BDBM50269901 (CHEMBL525748 | TPRARRRKKRI) Show SMILES [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6@@H](-[#7])-[#6@@H](-[#6])-[#8])-[#6](-[#7])=O |r| Show InChI InChI=1S/C60H117N29O12/c1-5-32(2)44(45(64)91)88-53(99)41(22-14-30-79-60(73)74)86-49(95)36(17-7-9-25-62)82-48(94)35(16-6-8-24-61)83-51(97)39(20-12-28-77-58(69)70)85-52(98)40(21-13-29-78-59(71)72)84-50(96)38(19-11-27-76-57(67)68)81-46(92)33(3)80-47(93)37(18-10-26-75-56(65)66)87-54(100)42-23-15-31-89(42)55(101)43(63)34(4)90/h32-44,90H,5-31,61-63H2,1-4H3,(H2,64,91)(H,80,93)(H,81,92)(H,82,94)(H,83,97)(H,84,96)(H,85,98)(H,86,95)(H,87,100)(H,88,99)(H4,65,66,75)(H4,67,68,76)(H4,69,70,77)(H4,71,72,78)(H4,73,74,79)/t32-,33-,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	562	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Medical Research Curated by ChEMBL					Assay Description Inhibition of human recombinant PC4 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage				J Biol Chem 282: 20847-53 (2007) Article DOI: 10.1074/jbc.M703847200 BindingDB Entry DOI: 10.7270/Q2057FPB
					More data for this Ligand-Target Pair