BDBM50269929 (2S,5S)-2-Hydroxymethyl-5-[1'-2'-(2''-naphtyl)}-ethynyl]-1-aza-bicyclo-[2.2.2]-octane::CHEMBL517050

SMILES: OC[C@@H]1CC2CCN1C[C@@H]2C#Cc1ccc2ccccc2c1

InChI Key: InChIKey=TWIMLFNHIWESPZ-YPJRHXLCSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50269929   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Farnesyltransferase, putative (Leishmania major)	BDBM50269929 ((2S,5S)-2-Hydroxymethyl-5-[1'-2'-(2''-naphtyl)}-et...) Show SMILES OC[C@@H]1CC2CCN1C[C@@H]2C#Cc1ccc2ccccc2c1 |r| Show InChI InChI=1S/C20H21NO/c22-14-20-12-18-9-10-21(20)13-19(18)8-6-15-5-7-16-3-1-2-4-17(16)11-15/h1-5,7,11,18-20,22H,9-10,12-14H2/t18?,19-,20-/m0/s1	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter				Antimicrob Agents Chemother 51: 4049-61 (2007) Article DOI: 10.1128/AAC.00205-07 BindingDB Entry DOI: 10.7270/Q2MS3SJZ
					More data for this Ligand-Target Pair