Found 3 hits for monomerid = 50269978 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Parathyroid hormone receptor
(Homo sapiens (Human)) | BDBM50269978
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Fl...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:62.61,8.12,81.81,97.97,25.25,wD:55.55,44.44,4.4,29.34,92.93,72.72,130.134,16.21,(17.08,-55.29,;15.74,-54.54,;15.72,-53,;14.37,-52.25,;14.35,-50.72,;13.05,-49.9,;11.68,-50.63,;11.69,-52.18,;10.41,-49.76,;10.41,-48.21,;11.75,-47.44,;11.75,-45.89,;13.08,-48.22,;9.18,-50.66,;7.82,-49.93,;7.82,-48.38,;6.54,-50.81,;6.54,-52.35,;7.88,-53.13,;7.88,-54.66,;6.54,-55.44,;9.21,-55.44,;5.33,-49.91,;3.96,-50.65,;3.97,-52.2,;2.68,-49.78,;1.46,-50.68,;.1,-49.96,;.11,-48.4,;-1.17,-50.82,;-1.17,-52.37,;.16,-53.14,;.16,-54.68,;-1.17,-55.47,;1.5,-55.47,;-2.39,-49.93,;-3.75,-50.66,;-3.74,-52.21,;-5.02,-49.78,;-4.21,-48.48,;-5.88,-51.07,;-6.33,-49.03,;-6.37,-47.49,;-5.03,-46.73,;-7.78,-46.8,;-7.77,-45.29,;-9.18,-44.63,;-10.4,-45.56,;-9.17,-43.1,;-7.63,-43.08,;-10.7,-43.12,;-9.19,-41.56,;-9.11,-47.57,;-9.14,-49.11,;-10.44,-46.79,;2.68,-48.23,;4.02,-47.46,;1.34,-47.45,;1.33,-45.91,;15.54,-49.93,;15.55,-48.38,;16.91,-50.66,;18.13,-49.76,;18.13,-48.22,;19.47,-47.44,;20.94,-47.94,;21.86,-46.7,;20.97,-45.43,;19.48,-45.89,;19.42,-50.64,;19.42,-52.19,;20.78,-49.91,;22,-50.8,;22,-52.35,;23.33,-53.12,;23.33,-54.66,;22,-55.44,;24.68,-55.43,;23.28,-49.93,;23.29,-48.38,;24.65,-50.66,;25.87,-49.77,;25.87,-48.22,;27.21,-47.45,;27.21,-45.9,;28.54,-45.13,;28.54,-43.6,;29.87,-42.83,;27.21,-42.83,;27.15,-50.64,;27.15,-52.19,;28.51,-49.91,;29.72,-50.81,;29.73,-52.35,;31.01,-49.93,;31.01,-48.38,;32.36,-50.66,;33.68,-49.87,;33.68,-48.34,;32.34,-47.58,;32.33,-46.04,;31,-45.28,;30.97,-43.74,;32.28,-42.95,;33.63,-43.7,;32.25,-41.42,;30.72,-41.45,;29.92,-40.13,;30.67,-38.78,;32.2,-38.76,;32.99,-40.08,;34.52,-40.06,;35.27,-38.71,;34.48,-37.39,;35.23,-36.05,;36.77,-36.03,;37.52,-34.69,;37.56,-37.34,;36.82,-38.69,;37.62,-40.01,;36.85,-41.36,;37.65,-42.68,;36.89,-44.03,;37.67,-45.35,;35.35,-44.05,;34.56,-42.72,;35.31,-41.38,;35.02,-50.64,;35.03,-52.17,;36.35,-49.86,;37.68,-50.62,;37.69,-52.15,;39.03,-52.92,;39.02,-54.45,;40.36,-55.21,;41.69,-54.44,;43.02,-55.2,;41.67,-52.89,;40.34,-52.14,;39.01,-49.84,;40.34,-50.6,;39,-48.31,)| Show InChI InChI=1S/C96H137N23O23/c1-13-15-23-62(110-88(136)69(42-49(3)4)114-86(134)66(35-38-74(98)124)112-90(138)78(51(7)14-2)117-87(135)67(36-39-75(125)126)116-93(141)96(11,12)119-91(139)77(50(5)6)118-92(140)95(9,10)102)84(132)115-70(44-54-47-103-48-106-54)89(137)111-65(34-37-73(97)123)85(133)109-64(25-20-41-105-94(100)101)82(130)107-52(8)80(128)108-63(83(131)113-68(79(99)127)43-53-26-28-55(120)29-27-53)24-18-19-40-104-81(129)59-22-17-16-21-58(59)76-60-32-30-56(121)45-71(60)142-72-46-57(122)31-33-61(72)76/h16-17,21-22,26-33,45-52,62-70,77-78,120-121H,13-15,18-20,23-25,34-44,102H2,1-12H3,(H2,97,123)(H2,98,124)(H2,99,127)(H,103,106)(H,104,129)(H,107,130)(H,108,128)(H,109,133)(H,110,136)(H,111,137)(H,112,138)(H,113,131)(H,114,134)(H,115,132)(H,116,141)(H,117,135)(H,118,140)(H,119,139)(H,125,126)(H4,100,101,105)/t51-,52-,62-,63-,64-,65-,66-,67-,68-,69-,70-,77-,78-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone receptor
(Homo sapiens (Human)) | BDBM50269978
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Fl...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:62.61,8.12,81.81,97.97,25.25,wD:55.55,44.44,4.4,29.34,92.93,72.72,130.134,16.21,(17.08,-55.29,;15.74,-54.54,;15.72,-53,;14.37,-52.25,;14.35,-50.72,;13.05,-49.9,;11.68,-50.63,;11.69,-52.18,;10.41,-49.76,;10.41,-48.21,;11.75,-47.44,;11.75,-45.89,;13.08,-48.22,;9.18,-50.66,;7.82,-49.93,;7.82,-48.38,;6.54,-50.81,;6.54,-52.35,;7.88,-53.13,;7.88,-54.66,;6.54,-55.44,;9.21,-55.44,;5.33,-49.91,;3.96,-50.65,;3.97,-52.2,;2.68,-49.78,;1.46,-50.68,;.1,-49.96,;.11,-48.4,;-1.17,-50.82,;-1.17,-52.37,;.16,-53.14,;.16,-54.68,;-1.17,-55.47,;1.5,-55.47,;-2.39,-49.93,;-3.75,-50.66,;-3.74,-52.21,;-5.02,-49.78,;-4.21,-48.48,;-5.88,-51.07,;-6.33,-49.03,;-6.37,-47.49,;-5.03,-46.73,;-7.78,-46.8,;-7.77,-45.29,;-9.18,-44.63,;-10.4,-45.56,;-9.17,-43.1,;-7.63,-43.08,;-10.7,-43.12,;-9.19,-41.56,;-9.11,-47.57,;-9.14,-49.11,;-10.44,-46.79,;2.68,-48.23,;4.02,-47.46,;1.34,-47.45,;1.33,-45.91,;15.54,-49.93,;15.55,-48.38,;16.91,-50.66,;18.13,-49.76,;18.13,-48.22,;19.47,-47.44,;20.94,-47.94,;21.86,-46.7,;20.97,-45.43,;19.48,-45.89,;19.42,-50.64,;19.42,-52.19,;20.78,-49.91,;22,-50.8,;22,-52.35,;23.33,-53.12,;23.33,-54.66,;22,-55.44,;24.68,-55.43,;23.28,-49.93,;23.29,-48.38,;24.65,-50.66,;25.87,-49.77,;25.87,-48.22,;27.21,-47.45,;27.21,-45.9,;28.54,-45.13,;28.54,-43.6,;29.87,-42.83,;27.21,-42.83,;27.15,-50.64,;27.15,-52.19,;28.51,-49.91,;29.72,-50.81,;29.73,-52.35,;31.01,-49.93,;31.01,-48.38,;32.36,-50.66,;33.68,-49.87,;33.68,-48.34,;32.34,-47.58,;32.33,-46.04,;31,-45.28,;30.97,-43.74,;32.28,-42.95,;33.63,-43.7,;32.25,-41.42,;30.72,-41.45,;29.92,-40.13,;30.67,-38.78,;32.2,-38.76,;32.99,-40.08,;34.52,-40.06,;35.27,-38.71,;34.48,-37.39,;35.23,-36.05,;36.77,-36.03,;37.52,-34.69,;37.56,-37.34,;36.82,-38.69,;37.62,-40.01,;36.85,-41.36,;37.65,-42.68,;36.89,-44.03,;37.67,-45.35,;35.35,-44.05,;34.56,-42.72,;35.31,-41.38,;35.02,-50.64,;35.03,-52.17,;36.35,-49.86,;37.68,-50.62,;37.69,-52.15,;39.03,-52.92,;39.02,-54.45,;40.36,-55.21,;41.69,-54.44,;43.02,-55.2,;41.67,-52.89,;40.34,-52.14,;39.01,-49.84,;40.34,-50.6,;39,-48.31,)| Show InChI InChI=1S/C96H137N23O23/c1-13-15-23-62(110-88(136)69(42-49(3)4)114-86(134)66(35-38-74(98)124)112-90(138)78(51(7)14-2)117-87(135)67(36-39-75(125)126)116-93(141)96(11,12)119-91(139)77(50(5)6)118-92(140)95(9,10)102)84(132)115-70(44-54-47-103-48-106-54)89(137)111-65(34-37-73(97)123)85(133)109-64(25-20-41-105-94(100)101)82(130)107-52(8)80(128)108-63(83(131)113-68(79(99)127)43-53-26-28-55(120)29-27-53)24-18-19-40-104-81(129)59-22-17-16-21-58(59)76-60-32-30-56(121)45-71(60)142-72-46-57(122)31-33-61(72)76/h16-17,21-22,26-33,45-52,62-70,77-78,120-121H,13-15,18-20,23-25,34-44,102H2,1-12H3,(H2,97,123)(H2,98,124)(H2,99,127)(H,103,106)(H,104,129)(H,107,130)(H,108,128)(H,109,133)(H,110,136)(H,111,137)(H,112,138)(H,113,131)(H,114,134)(H,115,132)(H,116,141)(H,117,135)(H,118,140)(H,119,139)(H,125,126)(H4,100,101,105)/t51-,52-,62-,63-,64-,65-,66-,67-,68-,69-,70-,77-,78-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.920 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in HEK293 cells assessed as induction of luciferase activity by CRE-luciferase reporter ... |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
Parathyroid hormone receptor
(Homo sapiens (Human)) | BDBM50269978
(Aib-Val-Aib-Glu-lle-Gln-Leu-Nle-His-Gln-Arg-Ala-Fl...)Show SMILES CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)c1ccccc1-c1c2ccc(O)cc2oc2cc(=O)ccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r,wU:62.61,8.12,81.81,97.97,25.25,wD:55.55,44.44,4.4,29.34,92.93,72.72,130.134,16.21,(17.08,-55.29,;15.74,-54.54,;15.72,-53,;14.37,-52.25,;14.35,-50.72,;13.05,-49.9,;11.68,-50.63,;11.69,-52.18,;10.41,-49.76,;10.41,-48.21,;11.75,-47.44,;11.75,-45.89,;13.08,-48.22,;9.18,-50.66,;7.82,-49.93,;7.82,-48.38,;6.54,-50.81,;6.54,-52.35,;7.88,-53.13,;7.88,-54.66,;6.54,-55.44,;9.21,-55.44,;5.33,-49.91,;3.96,-50.65,;3.97,-52.2,;2.68,-49.78,;1.46,-50.68,;.1,-49.96,;.11,-48.4,;-1.17,-50.82,;-1.17,-52.37,;.16,-53.14,;.16,-54.68,;-1.17,-55.47,;1.5,-55.47,;-2.39,-49.93,;-3.75,-50.66,;-3.74,-52.21,;-5.02,-49.78,;-4.21,-48.48,;-5.88,-51.07,;-6.33,-49.03,;-6.37,-47.49,;-5.03,-46.73,;-7.78,-46.8,;-7.77,-45.29,;-9.18,-44.63,;-10.4,-45.56,;-9.17,-43.1,;-7.63,-43.08,;-10.7,-43.12,;-9.19,-41.56,;-9.11,-47.57,;-9.14,-49.11,;-10.44,-46.79,;2.68,-48.23,;4.02,-47.46,;1.34,-47.45,;1.33,-45.91,;15.54,-49.93,;15.55,-48.38,;16.91,-50.66,;18.13,-49.76,;18.13,-48.22,;19.47,-47.44,;20.94,-47.94,;21.86,-46.7,;20.97,-45.43,;19.48,-45.89,;19.42,-50.64,;19.42,-52.19,;20.78,-49.91,;22,-50.8,;22,-52.35,;23.33,-53.12,;23.33,-54.66,;22,-55.44,;24.68,-55.43,;23.28,-49.93,;23.29,-48.38,;24.65,-50.66,;25.87,-49.77,;25.87,-48.22,;27.21,-47.45,;27.21,-45.9,;28.54,-45.13,;28.54,-43.6,;29.87,-42.83,;27.21,-42.83,;27.15,-50.64,;27.15,-52.19,;28.51,-49.91,;29.72,-50.81,;29.73,-52.35,;31.01,-49.93,;31.01,-48.38,;32.36,-50.66,;33.68,-49.87,;33.68,-48.34,;32.34,-47.58,;32.33,-46.04,;31,-45.28,;30.97,-43.74,;32.28,-42.95,;33.63,-43.7,;32.25,-41.42,;30.72,-41.45,;29.92,-40.13,;30.67,-38.78,;32.2,-38.76,;32.99,-40.08,;34.52,-40.06,;35.27,-38.71,;34.48,-37.39,;35.23,-36.05,;36.77,-36.03,;37.52,-34.69,;37.56,-37.34,;36.82,-38.69,;37.62,-40.01,;36.85,-41.36,;37.65,-42.68,;36.89,-44.03,;37.67,-45.35,;35.35,-44.05,;34.56,-42.72,;35.31,-41.38,;35.02,-50.64,;35.03,-52.17,;36.35,-49.86,;37.68,-50.62,;37.69,-52.15,;39.03,-52.92,;39.02,-54.45,;40.36,-55.21,;41.69,-54.44,;43.02,-55.2,;41.67,-52.89,;40.34,-52.14,;39.01,-49.84,;40.34,-50.6,;39,-48.31,)| Show InChI InChI=1S/C96H137N23O23/c1-13-15-23-62(110-88(136)69(42-49(3)4)114-86(134)66(35-38-74(98)124)112-90(138)78(51(7)14-2)117-87(135)67(36-39-75(125)126)116-93(141)96(11,12)119-91(139)77(50(5)6)118-92(140)95(9,10)102)84(132)115-70(44-54-47-103-48-106-54)89(137)111-65(34-37-73(97)123)85(133)109-64(25-20-41-105-94(100)101)82(130)107-52(8)80(128)108-63(83(131)113-68(79(99)127)43-53-26-28-55(120)29-27-53)24-18-19-40-104-81(129)59-22-17-16-21-58(59)76-60-32-30-56(121)45-71(60)142-72-46-57(122)31-33-61(72)76/h16-17,21-22,26-33,45-52,62-70,77-78,120-121H,13-15,18-20,23-25,34-44,102H2,1-12H3,(H2,97,123)(H2,98,124)(H2,99,127)(H,103,106)(H,104,129)(H,107,130)(H,108,128)(H,109,133)(H,110,136)(H,111,137)(H,112,138)(H,113,131)(H,114,134)(H,115,132)(H,116,141)(H,117,135)(H,118,140)(H,119,139)(H,125,126)(H4,100,101,105)/t51-,52-,62-,63-,64-,65-,66-,67-,68-,69-,70-,77-,78-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 7.20 | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Activity at human PTH/PTH-related peptide receptor expressed in SAOS2 cells assessed as cAMP formation |
Proc Natl Acad Sci U S A 104: 6846-51 (2007)
Article DOI: 10.1073/pnas.0605125104
BindingDB Entry DOI: 10.7270/Q28P608V |
More data for this
Ligand-Target Pair | |
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