BindingDB PrimarySearch

BDBM50269979 CHEMBL515170::r-5-(2-E-cyclopropylvinyl)-t-3-ethyl-6,7-difluoro-5-(trifluoromethyl)benzo[e][1,4]-oxazepin-2(1H,3H,5H)-one

SMILES: CC[C@@H]1O[C@@](\C=C\C2CC2)(c2c(F)c(F)ccc2NC1=O)C(F)(F)F

InChI Key: InChIKey=MSJCAWWJIHDUAU-OSTNNTLRSA-N

Data: 7 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50269979
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Parathyroid hormone receptor (Homo sapiens (Human))	BDBM50269979 (CHEMBL515170 \| r-5-(2-E-cyclopropylvinyl)-t-3-ethy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Antagonist activity at PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells assessed as inhibition of parathyroid hormone (1...				Proc Natl Acad Sci U S A 104: 6846-51 (2007) Article DOI: 10.1073/pnas.0605125104 BindingDB Entry DOI: 10.7270/Q28P608V
Pharmaceutical Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50269979 (CHEMBL515170 \| r-5-(2-E-cyclopropylvinyl)-t-3-ethy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of 5HT2A receptor (unknown origin)				Proc Natl Acad Sci U S A 104: 6846-51 (2007) Article DOI: 10.1073/pnas.0605125104 BindingDB Entry DOI: 10.7270/Q28P608V
Pharmaceutical Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1D adrenergic receptor (Homo sapiens (Human))	BDBM50269979 (CHEMBL515170 \| r-5-(2-E-cyclopropylvinyl)-t-3-ethy...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of adrenergic alpha1D receptor (unknown origin)				Proc Natl Acad Sci U S A 104: 6846-51 (2007) Article DOI: 10.1073/pnas.0605125104 BindingDB Entry DOI: 10.7270/Q28P608V
Pharmaceutical Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Parathyroid hormone receptor (Homo sapiens (Human))	BDBM50269979 (CHEMBL515170 \| r-5-(2-E-cyclopropylvinyl)-t-3-ethy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	990	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells				Proc Natl Acad Sci U S A 104: 6846-51 (2007) Article DOI: 10.1073/pnas.0605125104 BindingDB Entry DOI: 10.7270/Q28P608V
Pharmaceutical Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50269979 (CHEMBL515170 \| r-5-(2-E-cyclopropylvinyl)-t-3-ethy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of adrenergic alpha2C receptor (unknown origin)				Proc Natl Acad Sci U S A 104: 6846-51 (2007) Article DOI: 10.1073/pnas.0605125104 BindingDB Entry DOI: 10.7270/Q28P608V
Pharmaceutical Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Parathyroid hormone receptor (Homo sapiens (Human))	BDBM50269979 (CHEMBL515170 \| r-5-(2-E-cyclopropylvinyl)-t-3-ethy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Antagonist activity at PTH/PTH-related peptide receptor (unknown origin) expressed in HKRK-B28 cells assessed as inhibition of DPC-AJ1951-induced cAM...				Proc Natl Acad Sci U S A 104: 6846-51 (2007) Article DOI: 10.1073/pnas.0605125104 BindingDB Entry DOI: 10.7270/Q28P608V
Pharmaceutical Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Neurokinin 2 receptor (Homo sapiens (Human))	BDBM50269979 (CHEMBL515170 \| r-5-(2-E-cyclopropylvinyl)-t-3-ethy...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of neurokinin 2 receptor (unknown origin)				Proc Natl Acad Sci U S A 104: 6846-51 (2007) Article DOI: 10.1073/pnas.0605125104 BindingDB Entry DOI: 10.7270/Q28P608V
Pharmaceutical Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair