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BDBM50270315 3-[1'-{4'-(tert-Butyldimethylsilyloxy)-phenyl}]-quinuclidine-2-ene::CHEMBL518134

SMILES: CC(C)(C)[Si](C)(C)Oc1ccc(cc1)C1=CN2CCC1CC2

InChI Key: InChIKey=IJLZJMXSMXMVHL-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50270315   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Farnesyltransferase, putative


(Leishmania major)		BDBM50270315
PNG
(3-[1'-{4'-(tert-Butyldimethylsilyloxy)-phenyl}]-qu...)
Show SMILES CC(C)(C)[Si](C)(C)Oc1ccc(cc1)C1=CN2CCC1CC2 |t:15,(30.85,1.27,;29.53,2.04,;30.3,3.38,;28.75,.71,;28.2,2.81,;28.97,4.14,;27.45,1.47,;26.87,3.58,;25.54,2.81,;25.54,1.27,;24.2,.5,;22.87,1.27,;22.87,2.81,;24.2,3.58,;21.54,.5,;21.54,-1.04,;20.2,-1.81,;18.86,-1.04,;18.86,.5,;20.2,1.28,;19.46,-.08,;20.95,-.48,)|
Show InChI InChI=1S/C19H29NOSi/c1-19(2,3)22(4,5)21-17-8-6-15(7-9-17)18-14-20-12-10-16(18)11-13-20/h6-9,14,16H,10-13H2,1-5H3
KEGG

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter

Antimicrob Agents Chemother 51: 4049-61 (2007)


Article DOI: 10.1128/AAC.00205-07
BindingDB Entry DOI: 10.7270/Q2MS3SJZ
More data for this
Ligand-Target Pair