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BDBM50270681 CHEMBL487307::[5-(4-Chlorophenyl)-furan-2-yl]-[4-(3-trifluoromethylphenyl)-piperazin-1-yl]-methanone

SMILES: FC(F)(F)c1cccc(c1)N1CCN(CC1)C(=O)c1ccc(o1)-c1ccc(Cl)cc1

InChI Key: InChIKey=XGVHEGGVYVHPBP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50270681   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type X alpha subunit


(Mus musculus)
BDBM50270681
PNG
(CHEMBL487307 | [5-(4-Chlorophenyl)-furan-2-yl]-[4-...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CC1)C(=O)c1ccc(o1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H18ClF3N2O2/c23-17-6-4-15(5-7-17)19-8-9-20(30-19)21(29)28-12-10-27(11-13-28)18-3-1-2-16(14-18)22(24,25)26/h1-9,14H,10-13H2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.40E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant Nav1.8 channel expressed in HEK293 cells by isotopic efflux assay


Bioorg Med Chem 16: 6379-86 (2008)


Article DOI: 10.1016/j.bmc.2008.05.003
BindingDB Entry DOI: 10.7270/Q2VH5NNT
More data for this
Ligand-Target Pair