BDBM50272597 (trans-2-(4-chlorobenzyl)-3-(4-chlorophenyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4 carboxylic acid)::CHEMBL497305
SMILES: OC(=O)[C@H]1[C@@H](N(Cc2ccc(Cl)cc2)C(=O)c2ccccc12)c1ccc(Cl)cc1
InChI Key: InChIKey=XIYILCWDRBCFJW-RTWAWAEBSA-N
Data: 3 Kd
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MDM2-MDMX (Homo sapiens (Human)) | BDBM50272597 ((trans-2-(4-chlorobenzyl)-3-(4-chlorophenyl)-1-oxo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a |
Institute for Biochemistry Curated by ChEMBL | Assay Description Binding affinity to human wild type Mdm2 by NMR ligand-protein binary titration | J Med Chem 51: 5035-42 (2008) Article DOI: 10.1021/jm8002813 BindingDB Entry DOI: 10.7270/Q2CZ3821 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MDM2-MDMX (Homo sapiens (Human)) | BDBM50272597 ((trans-2-(4-chlorobenzyl)-3-(4-chlorophenyl)-1-oxo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a |
Institute for Biochemistry Curated by ChEMBL | Assay Description Binding affinity to human wild type Mdm2 by NMR ligand-protein binary titration | J Med Chem 51: 5035-42 (2008) Article DOI: 10.1021/jm8002813 BindingDB Entry DOI: 10.7270/Q2CZ3821 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MDM2-MDMX (Homo sapiens (Human)) | BDBM50272597 ((trans-2-(4-chlorobenzyl)-3-(4-chlorophenyl)-1-oxo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a |
Institute for Biochemistry Curated by ChEMBL | Assay Description Binding affinity to human wild type Mdm2 by isothermal titration calorimetry | J Med Chem 51: 5035-42 (2008) Article DOI: 10.1021/jm8002813 BindingDB Entry DOI: 10.7270/Q2CZ3821 | |||||||||||
More data for this Ligand-Target Pair |