BDBM50273449 CHEMBL455894::N-Cyclopropyl-4-{2-[(S)-1-(4-fluorophenyl)ethylamino]-5-methyl-4-oxo-4,5-dihydrothiazol-5-yl}benzamide

SMILES: C[C@H](NC1=NC(=O)C(C)(S1)c1ccc(cc1)C(=O)NC1CC1)c1ccc(F)cc1

InChI Key: InChIKey=VSKLTPJPTOYPER-JHAYDQECSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50273449   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50273449 (CHEMBL455894 | N-Cyclopropyl-4-{2-[(S)-1-(4-fluoro...) Show SMILES C[C@H](NC1=NC(=O)C(C)(S1)c1ccc(cc1)C(=O)NC1CC1)c1ccc(F)cc1 |r,t:3| Show InChI InChI=1S/C22H22FN3O2S/c1-13(14-5-9-17(23)10-6-14)24-21-26-20(28)22(2,29-21)16-7-3-15(4-8-16)19(27)25-18-11-12-18/h3-10,13,18H,11-12H2,1-2H3,(H,25,27)(H,24,26,28)/t13-,22?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	240	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay				J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7
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