BDBM50273821 CHEMBL458085::Methyl 4-{2-[(S)-1-(4-fluorophenyl)ethylamino]-5-methyl-4-oxo-4,5-dihydrothiazol-5-yl}benzoate

SMILES: COC(=O)c1ccc(cc1)C1(C)SC(N[C@@H](C)c2ccc(F)cc2)=NC1=O

InChI Key: InChIKey=XGZFRGZBEHDKKL-SVZXGPMESA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50273821   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50273821 (CHEMBL458085 | Methyl 4-{2-[(S)-1-(4-fluorophenyl)...) Show SMILES COC(=O)c1ccc(cc1)C1(C)SC(N[C@@H](C)c2ccc(F)cc2)=NC1=O |r,c:25| Show InChI InChI=1S/C20H19FN2O3S/c1-12(13-6-10-16(21)11-7-13)22-19-23-18(25)20(2,27-19)15-8-4-14(5-9-15)17(24)26-3/h4-12H,1-3H3,(H,22,23,25)/t12-,20?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay				J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7
					More data for this Ligand-Target Pair